Immunology Antibodies 3
Anti-PRKRA Antibody (CAB8779)
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- SKU:
- CAB8779
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-PRKRA Antibody |
| Antibody SKU: | CAB8779 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PRKRA |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, PC-12, Mouse testis |
| Immunogen: | A synthesized peptide derived from human PRKRA |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8575 |
| Uniprot: | O75569 |
| Cellular Location: | |
| Calculated MW: | 34kDa |
| Observed MW: | 34KDa |
| Synonyms: | DYT16, HSD14, PACT, RAX |
| Background: | This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| UniProt Protein Function: | PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported. |
| UniProt Protein Details: | Protein type:Activator; RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol Molecular Function:protein binding; protein homodimerization activity; enzyme activator activity Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; immune response; gene expression; middle ear morphogenesis; RNA interference, production of siRNA; protein amino acid phosphorylation Disease: Dystonia 16 |
| NCBI Summary: | This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| UniProt Code: | O75569 |
| NCBI GenInfo Identifier: | 74735517 |
| NCBI Gene ID: | 8575 |
| NCBI Accession: | O75569.1 |
| UniProt Secondary Accession: | O75569,Q53G24, Q6X7T5, Q8NDK4, A8K3I6, |
| UniProt Related Accession: | O75569 |
| Molecular Weight: | 313 |
| NCBI Full Name: | Interferon-inducible double-stranded RNA-dependent protein kinase activator A |
| NCBI Synonym Full Names: | protein kinase, interferon-inducible double stranded RNA dependent activator |
| NCBI Official Symbol: | PRKRA |
| NCBI Official Synonym Symbols: | RAX; PACT; DYT16; HSD14 |
| NCBI Protein Information: | interferon-inducible double-stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator; interferon-inducible double stranded RNA-dependent protein kinase activator A |
| UniProt Protein Name: | Interferon-inducible double-stranded RNA-dependent protein kinase activator A |
| UniProt Synonym Protein Names: | PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator |
| Protein Family: | Interferon-inducible double-stranded RNA-dependent protein kinase activator |
| UniProt Gene Name: | PRKRA |
| UniProt Entry Name: | PRKRA_HUMAN |
 | Western blot - PRKRA Rabbit mAb (CAB8779) |
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