Anti-PRKCSH Antibody (CAB4045)
- SKU:
- CAB4045
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PRKCSH
- Synonyms:
- AGE-R2
- Synonyms:
- G19P1
- Synonyms:
- GIIB
- Synonyms:
- PCLD
- Synonyms:
- PCLD1
- Synonyms:
- PKCSH
- Synonyms:
- PLD1
- Synonyms:
- VASAP-60
Description
| Product Name: | PRKCSH Rabbit pAb |
| Product Code: | CAB4045 |
| Size: | 100uL |
| Synonyms: | PRKCSH, AGE-R2, G19P1, GIIB, PCLD, PCLD1, PKCSH, PLD1, VASAP-60 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human PRKCSH |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, A-549, Mouse lung, Rat brain |
| Immunogen: | A synthetic Peptide of human PRKCSH |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5589 |
| Uniprot: | P14314 |
| Cellular Location: | Endoplasmic reticulum |
| Calculated MW: | 59kDa |
| Observed MW: | 80KDa |
| UniProt Protein Function: | PRKCSH: Regulatory subunit of glucosidase II. Defects in PRKCSH are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. PCLD is a distinct clinical and genetic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD), which in a considerable but uncertain proportion of cases is associated with hepatic cysts. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; intracellular Molecular Function:protein kinase C binding; phosphoprotein binding; calcium ion binding Biological Process: cellular protein metabolic process; protein folding; innate immune response; protein amino acid N-linked glycosylation via asparagine; N-glycan processing; post-translational protein modification Disease: Polycystic Liver Disease |
| NCBI Summary: | This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P14314 |
| NCBI GenInfo Identifier: | 116242499 |
| NCBI Gene ID: | 5589 |
| NCBI Accession: | P14314.2 |
| UniProt Secondary Accession: | P14314,Q96BU9, Q96D06, Q9P0W9, A8K318, |
| UniProt Related Accession: | P14314 |
| Molecular Weight: | 528 |
| NCBI Full Name: | Glucosidase 2 subunit beta |
| NCBI Synonym Full Names: | protein kinase C substrate 80K-H |
| NCBI Official Symbol: | PRKCSH |
| NCBI Official Synonym Symbols: | PCLD; PLD1; G19P1; PKCSH; AGE-R2 |
| NCBI Protein Information: | glucosidase 2 subunit beta; hepatocystin; AGE-binding receptor 2; glucosidase II subunit beta; protein kinase C substrate, 80 Kda protein; protein kinase C substrate 60.1 kDa protein heavy chain |
| UniProt Protein Name: | Glucosidase 2 subunit beta |
| UniProt Synonym Protein Names: | 80K-H protein; Glucosidase II subunit beta; Protein kinase C substrate 60.1 kDa protein heavy chain; PKCSH |
| Protein Family: | Glucosidase |
| UniProt Gene Name: | PRKCSH |
| UniProt Entry Name: | GLU2B_HUMAN |
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