Cell Biology Antibodies 11

Anti-PRKACG Antibody (CAB7715)

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SKU:
CAB7715
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PRKACG Antibody
Antibody SKU:CAB7715
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human PRKACG (NP_002723.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse testis, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human PRKACG (NP_002723.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGNA PAKK DTEQ EESV NEFL AKAR GDFL YRWG NPAQ NTAS SDQF ERLR TLGM GSFG RVML VRHQ ETGG HYAM KILN KQKV VKMK QVEH ILNE KRIL QAID FPFL VKLQ FSFK DNSY LYLV MEYV PGGE MFSR LQRV GRFS EPHA CFYA AQVV LAVQ YLHS LDLI HRDL KPEN LLID QQGY LQVT DFGF AKRV KGRT WTLC GTPE YLAP EIIL SKGY NKAV DWWA LGVL IYEM AVGF PPFY ADQP IQIY EKIV SGRV RFPS KLSS DLKH LLRS LLQV DLTK RFGN LRNG VGDI KNHK WFAT TSWI AIYE KKVE APFI PKYT GPGD ASNF DDYE EEEL RISI NEKC AKEF SEF
Gene ID:5568
Uniprot:P22612
Cellular Location:
Calculated MW:40kDa
Observed MW:42kDa
Synonyms:PRKACG, BDPLT19, KAPG, PKACg
Background:Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.
UniProt Protein Function:PKACG: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. Activated by cAMP. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
UniProt Protein Details:

Protein type:Protein kinase, AGC; EC 2.7.11.11; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKA family

Chromosomal Location of Human Ortholog: 9q13

Cellular Component: cytosol

Molecular Function:cAMP-dependent protein kinase activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; male gonad development; glucose metabolic process; pathogenesis; signal transduction; protein amino acid phosphorylation; gluconeogenesis; phospholipase C activation; triacylglycerol catabolic process; carbohydrate metabolic process; energy reserve metabolic process; innate immune response; renal water homeostasis; spermatogenesis; blood coagulation; regulation of insulin secretion; transmembrane transport

Disease: Mental Retardation, Autosomal Dominant 31

NCBI Summary:Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]
UniProt Code:P22612
NCBI GenInfo Identifier:207029159
NCBI Gene ID:5568
NCBI Accession:NP_002723.2
UniProt Secondary Accession:P22612,O60850, Q5VZ02, Q86YI1,
UniProt Related Accession:P22612
Molecular Weight:65.0 kDa
NCBI Full Name:Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma (PRKACG), mRNA
NCBI Synonym Full Names:protein kinase, cAMP-dependent, catalytic, gamma
NCBI Official Symbol:PRKACG  
NCBI Official Synonym Symbols:KAPG; PKACg; BDPLT19  
NCBI Protein Information:cAMP-dependent protein kinase catalytic subunit gamma
UniProt Protein Name:cAMP-dependent protein kinase catalytic subunit gamma
Protein Family:Protein lysine acetyltransferase
UniProt Gene Name:PRKACG  
UniProt Entry Name:KAPCG_HUMAN
Anti-PRKACG Antibody (CAB7715)Western blot analysis of extracts of various cell lines, using PRKACG antibody (CAB7715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PRKACG Antibody (CAB7715)Immunofluorescence analysis of A549 cells using PRKACG antibody (CAB7715). Blue: DAPI for nuclear staining.
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