Cell Biology Antibodies 11

Anti-PRICKLE2 Antibody (CAB8023)

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SKU:
CAB8023
Product Type:
Antibody
Applications:
WB
Applications:
IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:PRICKLE2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8023
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 615-844 of human PRICKLE2 (NP_942559.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 615-844 of human PRICKLE2 (NP_942559.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QEME GNLH QLSN PIGY RDLQ SHGR MHQS FDFD GGMA GSKL PGQE GVRI QPMS ERTR RRAT SRDD NRRF RPHR SRRS RRSR SDNA LHLA SERE AISR LKDR PPLR ARED YDQF MRQR SFQE SMGH GSRR DLYG QCPR TVSD LALQ NAFG DRWG PYFA EYDW CSTC SSSS ESDN EGYF LGEP IPQP ARLR YVTS DELL HKYS SYGL PKSS TLGG RGQL HSRK RQKS KNCI IS
Gene ID:166336
Uniprot:Q7Z3G6
Cellular Location:Nucleus membrane
Calculated MW:95kDa
Observed MW:126kDa
Synonyms:PRICKLE2, EPM5
Background:This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5.
UniProt Protein Function:PRICKLE2: Defects in PRICKLE2 are the cause of progressive myoclonic epilepsy type 5 (EPM5). EPM5 is a neurodegenerative disorder characterized by myoclonic seizures and variable neurologic symptoms including cognitive decline and persistent movement abnormalities. Belongs to the prickle / espinas / testin family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: nuclear membrane; apicolateral plasma membrane; cytoplasm; lateral plasma membrane

Molecular Function:zinc ion binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; neurite development

Disease: Epilepsy, Progressive Myoclonic 5

NCBI Summary:This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]
UniProt Code:Q7Z3G6
NCBI GenInfo Identifier:38524620
NCBI Gene ID:166336
NCBI Accession:NP_942559
UniProt Related Accession:Q7Z3G6
Molecular Weight:95kDa
NCBI Full Name:prickle-like protein 2
NCBI Synonym Full Names:prickle planar cell polarity protein 2
NCBI Official Symbol:PRICKLE2  
NCBI Official Synonym Symbols:EPM5  
NCBI Protein Information:prickle-like protein 2
UniProt Protein Name:Prickle-like protein 2
Protein Family:Prickle-like protein
UniProt Gene Name:PRICKLE2  
UniProt Entry Name:PRIC2_HUMAN
Anti-PRICKLE2 Polyclonal Antibody (CAB8023)Western blot analysis of extracts of various cell lines, using PRICKLE2 antibody (CAB8023) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PRICKLE2 Polyclonal Antibody (CAB8023)Immunofluorescence analysis of A549 cells using PRICKLE2 antibody (CAB8023).
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