Cell Biology Antibodies 10
Anti-PRDX5 Antibody (CAB6329)
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- SKU:
- CAB6329
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PRDX5 Antibody |
| Antibody SKU: | CAB6329 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 53-214 of human PRDX5 (NP_036226.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 53-214 of human PRDX5 (NP_036226.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAPI KVGD AIPA VEVF EGEP GNKV NLAE LFKG KKGV LFGV PGAF TPGC SKTH LPGF VEQA EALK AKGV QVVA CLSV NDAF VTGE WGRA HKAE GKVR LLAD PTGA FGKE TDLL LDDS LVSI FGNR RLKR FSMV VQDG IVKA LNVE PDGT GLTC SLAP NIIS QL |
| Gene ID: | 25824 |
| Uniprot: | P30044 |
| Cellular Location: | Cytoplasm, Mitochondrion, Peroxisome |
| Calculated MW: | 12kDa/17kDa/22kDa |
| Observed MW: | 17KDa |
| Synonyms: | PRDX5, ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V |
| Background: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | PRDX5: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling. Belongs to the peroxiredoxin 2 family. 2 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:EC 1.11.1.15; Oxidoreductase Chromosomal Location of Human Ortholog: 11q13 Cellular Component: peroxisomal matrix; extracellular space; intracellular membrane-bound organelle; mitochondrion; perinuclear region of cytoplasm; mitochondrial matrix; cytoplasm; peroxisome; cytoplasmic vesicle; cytosol; nucleus Molecular Function:antioxidant activity; protein dimerization activity; peroxidase activity; peroxiredoxin activity; caspase inhibitor activity; receptor binding Biological Process: response to reactive oxygen species; hydrogen peroxide catabolic process; negative regulation of transcription from RNA polymerase III promoter; positive regulation of collagen biosynthetic process; negative regulation of oxidoreductase activity; response to oxidative stress; negative regulation of caspase activity; inflammatory response; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30044 |
| NCBI GenInfo Identifier: | 317373539 |
| NCBI Gene ID: | 25824 |
| NCBI Accession: | P30044.4 |
| UniProt Secondary Accession: | P30044,Q14CK0, Q6IAF2, Q9UBU5, Q9UJU4, Q9UKX4, A6NC19 A6NG06, B7ZLJ4, B7ZVW3, |
| UniProt Related Accession: | P30044 |
| Molecular Weight: | 12,897 Da |
| NCBI Full Name: | Peroxiredoxin-5, mitochondrial |
| NCBI Synonym Full Names: | peroxiredoxin 5 |
| NCBI Official Symbol: | PRDX5 |
| NCBI Official Synonym Symbols: | PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55 |
| NCBI Protein Information: | peroxiredoxin-5, mitochondrial; TPx type VI; peroxiredoxin V; Alu co-repressor 1; thioredoxin reductase; antioxidant enzyme B166; thioredoxin peroxidase PMP20; liver tissue 2D-page spot 71B; peroxisomal antioxidant enzyme; epididymis secretory protein Li 55 |
| UniProt Protein Name: | Peroxiredoxin-5, mitochondrial |
| UniProt Synonym Protein Names: | Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin reductase |
| Protein Family: | Peroxiredoxin |
| UniProt Gene Name: | PRDX5 |
| UniProt Entry Name: | PRDX5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRDX5 antibody (CAB6329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Western blot analysis of extracts of Mouse lung, using PRDX5 antibody (CAB6329) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using PRDX5 antibody (CAB6329) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using PRDX5 Rabbit pAb (CAB6329) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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