Cell Biology Antibodies 15
Anti-PRDM16 Antibody (CAB18633)
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- SKU:
- CAB18633
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PRDM16 Antibody |
| Antibody SKU: | CAB18633 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PRDM16. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human PRDM16. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 63976 |
| Uniprot: | Q9HAZ2 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted Chromosomal Location of Human Ortholog: 1p36.23-p33 Cellular Component: cytosol; nucleus; transcriptional repressor complex Molecular Function:histone-lysine N-methyltransferase activity; protein binding; sequence-specific DNA binding; transcription activator binding; transcription coactivator activity Biological Process: brown fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of cellular respiration Disease: Left Ventricular Noncompaction 8 |
| NCBI Summary: | The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HAZ2 |
| NCBI GenInfo Identifier: | 259016328 |
| NCBI Gene ID: | 63976 |
| NCBI Accession: | Q9HAZ2.3 |
| UniProt Secondary Accession: | Q9HAZ2,Q8WYJ9, Q9C0I8, A6NHQ8, B1AJP7, B1AJP8, B1AJP9 B1WB48, |
| UniProt Related Accession: | Q9HAZ2 |
| Molecular Weight: | 140251 Da |
| NCBI Full Name: | PR domain zinc finger protein 16 |
| NCBI Synonym Full Names: | PR/SET domain 16 |
| NCBI Official Symbol: | PRDM16 |
| NCBI Official Synonym Symbols: | MEL1; LVNC8; PFM13; CMD1LL |
| NCBI Protein Information: | PR domain zinc finger protein 16 |
| UniProt Protein Name: | PR domain zinc finger protein 16 |
| UniProt Synonym Protein Names: | PR domain-containing protein 16 |
| Protein Family: | PR domain zinc finger protein |
| UniProt Gene Name: | PRDM16 |
| UniProt Entry Name: | PRD16_HUMAN |
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