Cell Biology Antibodies 9
Anti-PRCP Antibody (CAB4040)
- SKU:
- CAB4040
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-PRCP Antibody |
Antibody SKU: | CAB4040 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 407-496 of human PRCP (NP_005031.1). |
Application: | WB |
Recommended Dilution: | WB 1:1000 - 1:2000 |
Reactivity: | Rat |
Positive Samples: | Rat kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 407-496 of human PRCP (NP_005031.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | ITTM YGGK NISS HTNI VFSN GELD PWSG GGVT KDIT DTLV AVTI SEGA HHLD LRTK NALD PMSV LLAR SLEV RHMK NWIR DFYD SAGK QH |
Gene ID: | 5547 |
Uniprot: | P42785 |
Cellular Location: | Lysosome |
Calculated MW: | 55kDa/58kDa |
Observed MW: | 56kDa |
Synonyms: | PRCP, HUMPCP, PCP |
Background: | This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
UniProt Protein Function: | PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family. |
UniProt Protein Details: | Protein type:EC 3.4.16.2; Protease Chromosomal Location of Human Ortholog: 11q14 Cellular Component: lysosome; plasma membrane Molecular Function:serine carboxypeptidase activity; protein binding Biological Process: plasma kallikrein-kinin cascade; negative regulation of systemic arterial blood pressure; regulation of blood vessel endothelial cell migration; glucose homeostasis; proteolysis; blood coagulation; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway |
NCBI Summary: | This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | P42785 |
NCBI GenInfo Identifier: | 1172047 |
NCBI Gene ID: | 5547 |
NCBI Accession: | P42785.1 |
UniProt Related Accession: | P42785 |
Molecular Weight: | |
NCBI Full Name: | Lysosomal Pro-X carboxypeptidase |
NCBI Synonym Full Names: | prolylcarboxypeptidase |
NCBI Official Symbol: | PRCP |
NCBI Official Synonym Symbols: | PCP; HUMPCP |
NCBI Protein Information: | lysosomal Pro-X carboxypeptidase |
UniProt Protein Name: | Lysosomal Pro-X carboxypeptidase |
UniProt Synonym Protein Names: | Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP |
Protein Family: | Paracaspase |
UniProt Gene Name: | PRCP |
UniProt Entry Name: | PCP_HUMAN |
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