Cell Biology Antibodies 12
Anti-PPP6R2 Antibody (CAB8359)
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- SKU:
- CAB8359
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PPP6R2 Antibody |
| Antibody SKU: | CAB8359 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-959 of human PPP6R2 (NP_001229827.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2, 293T, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-959 of human PPP6R2 (NP_001229827.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EDSD TRCA ARVM ARPR FGAP HASE SCSK NGPE RGGQ DGKA SLEA HRDA PGAG APPA PGKK EAPP VEGD SEGA MWTA VFDE PANS TPTA PGVV RDVG SSVW AAGT SAPE EKGW AKFT DFQP FCCS ESGP RCSS PVDT ECSH AEGS RSQG PEKA FSPA SPCA WNVC VTRK APLL ASDS SSSG GSHS EDGD QKAA SAMD AVSR GPGR EAPP LPTV ARTE EAVG RVGC ADSR LLSP ACPA PKEV TAAP AVAV PPEA TVAI TTAL SKAG PAIP TPAV SSAL AVAV PLGP IMAV TAAP AMVA TLGT VTKD GKTD APPE GAAL NGPV |
| Gene ID: | 9701 |
| Uniprot: | O75170 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 98kDa/101kDa/104kDa |
| Observed MW: | 105kDa |
| Synonyms: | PPP6R2, KIAA0685, PP6R2, SAP190, SAPS2 |
| Background: | The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. |
| UniProt Protein Function: | SAPS2: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Belongs to the SAPS family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: cytoplasm; intracellular membrane-bound organelle Molecular Function:protein binding |
| NCBI Summary: | Protein phosphatase regulatory subunits, such as SAPS2, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS2 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | O75170 |
| NCBI GenInfo Identifier: | 166214976 |
| NCBI Gene ID: | 9701 |
| NCBI Accession: | O75170.2 |
| UniProt Secondary Accession: | O75170,Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9, A6PVG3 B7Z7T3, |
| UniProt Related Accession: | O75170 |
| Molecular Weight: | 98,126 Da |
| NCBI Full Name: | Serine/threonine-protein phosphatase 6 regulatory subunit 2 |
| NCBI Synonym Full Names: | protein phosphatase 6 regulatory subunit 2 |
| NCBI Official Symbol: | PPP6R2 |
| NCBI Official Synonym Symbols: | PP6R2; SAPS2; SAP190; KIAA0685 |
| NCBI Protein Information: | serine/threonine-protein phosphatase 6 regulatory subunit 2 |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 6 regulatory subunit 2 |
| UniProt Synonym Protein Names: | SAPS domain family member 2 |
| Protein Family: | Serine/threonine-protein phosphatase |
| UniProt Gene Name: | PPP6R2 |
| UniProt Entry Name: | PP6R2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPP6R2 antibody (CAB8359) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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