Cell Cycle Antibodies 1

Anti-PPP6C Antibody (CAB4039)

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SKU:
CAB4039
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-PPP6C Antibody
Antibody SKU:CAB4039
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human PPP6C (NP_002712.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, SH-SY5Y, HepG2, SW480, Mouse kidney, Mouse thymus, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human PPP6C (NP_002712.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPL DLDK YVEI ARLC KYLP ENDL KRLC DYVC DLLL EESN VQPV STPV TVCG DIHG QFYD LCEL FRTG GQVP DTNY IFMG DFVD RGYY SLET FTYL LALK AKWP DRIT LLRG NHES RQIT QVYG FYDE CQTK YGNA NAWR YCTK VFDM LTVA ALID EQIL CVHG GLSP DIKT LDQI RTIE RNQE IPHK GAFC DLVW SDPE DVDT WAIS PRGA GWLF GAKV TNEF VHIN NLKL ICRA HQLV HEGY KFMF DEKL VTVW SAPN YCYR CGNI ASIM VFKD VNTR EPKL FRAV PDSE RVIP PRTT TPYF L
Gene ID:5537
Uniprot:O00743
Cellular Location:Cytoplasm
Calculated MW:32kDa/35kDa/38kDa
Observed MW:35kDa
Synonyms:PPP6C, PP6, PP6C
Background:This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
UniProt Protein Function:PPP6C: a Ser/Thr phosphatase. A functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cytosol

Molecular Function:protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; G1/S transition of mitotic cell cycle

NCBI Summary:This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
UniProt Code:O00743
NCBI GenInfo Identifier:3183123
NCBI Gene ID:5537
NCBI Accession:O00743.1
UniProt Secondary Accession:O00743,Q9CQR6, Q64620,
UniProt Related Accession:O00743
Molecular Weight:305
NCBI Full Name:Serine/threonine-protein phosphatase 6 catalytic subunit
NCBI Synonym Full Names:protein phosphatase 6, catalytic subunit
NCBI Official Symbol:PPP6C  
NCBI Official Synonym Symbols:PP6; PP6C  
NCBI Protein Information:serine/threonine-protein phosphatase 6 catalytic subunit; serine/threonine protein phosphatase catalytic subunit
UniProt Protein Name:Serine/threonine-protein phosphatase 6 catalytic subunit
UniProt Gene Name:PPP6C  
UniProt Entry Name:PPP6_HUMAN
Anti-PPP6C Antibody (CAB4039)Western blot analysis of extracts of various cell lines, using PPP6C antibody (CAB4039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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