Cell Biology Antibodies 11
Anti-PPP3CC Antibody (CAB7714)
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- SKU:
- CAB7714
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PPP3CC Antibody |
| Antibody SKU: | CAB7714 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 373-512 of human PPP3CC (NP_005596.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 373-512 of human PPP3CC (NP_005596.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LISD DEAE GSTT VRKE IIRN KIRA IGKM ARVF SILR QESE SVLT LKGL TPTG TLPL GVLS GGKQ TIET ATVE AVEA REAI RGFS LQHK IRSF EEAR GLDR INER MPPR KDSI HAGG PMKS VTSA HSHA AHRS DQGK KAHS |
| Gene ID: | 5533 |
| Uniprot: | P48454 |
| Cellular Location: | |
| Calculated MW: | 57kDa/58kDa/59kDa |
| Observed MW: | 58kDa |
| Synonyms: | PPP3CC, CALNA3, CNA3, PP2Bgamma |
| Background: | Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PPP3CC: a calmodulin-dependent Ser/Thr phosphatase also known as calcineurin A gamma. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: cytosol Molecular Function:calmodulin binding; metal ion binding; phosphoprotein phosphatase activity Biological Process: dephosphorylation; apoptosis |
| NCBI Summary: | Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P48454 |
| NCBI GenInfo Identifier: | 257051041 |
| NCBI Gene ID: | 5533 |
| NCBI Accession: | P48454.3 |
| UniProt Related Accession: | P48454 |
| Molecular Weight: | |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| NCBI Synonym Full Names: | protein phosphatase 3 catalytic subunit gamma |
| NCBI Official Symbol: | PPP3CC |
| NCBI Official Synonym Symbols: | CNA3; CALNA3; PP2Bgamma |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
| UniProt Synonym Protein Names: | CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform |
| UniProt Gene Name: | PPP3CC |
| UniProt Entry Name: | PP2BC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPP3CC antibody (CAB7714) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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