Cell Biology Antibodies 8
Anti-PPP3CB Antibody (CAB3629)
- SKU:
- CAB3629
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PPP3CB Antibody |
| Antibody SKU: | CAB3629 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-525 of human PPP3CB (NP_001135825.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-525 of human PPP3CB (NP_001135825.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IIRA HEAQ DAGY RMYR KSQT TGFP SLIT IFSA PNYL DVYN NKAA VLKY ENNV MNIR QFNC SPHP YWLP NFMD VFTW SLPF VGEK VTEM LVNV LSIC SDDE LMTE GEDQ FDVG SAAA RKEI IRNK IRAI GKMA RVFS VLRE ESES VLTL KGLT PTGM LPSG VLAG GRQT LQSA TVEA IEAE KAIR GFSP PHRI CSFE EAKG LDRI NERM PPRK DAVQ QDGF NSLN TAHA TENH GTGN HTAQ |
| Gene ID: | 5532 |
| Uniprot: | P16298 |
| Cellular Location: | |
| Calculated MW: | 58kDa/59kDa |
| Observed MW: | 69kDa |
| Synonyms: | PPP3CB, CALNA2, CALNB, CNA2, PP2Bbeta |
| Background: |
| UniProt Protein Function: | PPP3CB: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A beta. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 10q22.2 Cellular Component: nucleoplasm; T-tubule; plasma membrane; Z disc; cytosol; calcineurin complex Molecular Function:protein dimerization activity; calmodulin binding; protein binding; enzyme binding; calmodulin-dependent protein phosphatase activity; calcium ion binding; protein serine/threonine phosphatase activity; drug binding; protein phosphatase 2B binding Biological Process: T cell activation; positive regulation of NFAT protein import into nucleus; axon extension; heart development; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; learning; social behavior; signal transduction; protein amino acid dephosphorylation; protein amino acid phosphorylation; memory; calcium ion-dependent exocytosis; locomotion during locomotory behavior; T cell proliferation; calcineurin-NFAT signaling pathway; dephosphorylation; response to cytokine stimulus; negative regulation of T cell mediated cytotoxicity; innate immune response; T cell homeostasis; positive regulation of transcription from RNA polymerase II promoter; regulation of insulin secretion; T cell differentiation |
| UniProt Code: | P16298 |
| NCBI GenInfo Identifier: | 60659599 |
| NCBI Gene ID: | 5532 |
| NCBI Accession: | P16298.2 |
| UniProt Related Accession: | P16298 |
| Molecular Weight: | |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform |
| NCBI Synonym Full Names: | protein phosphatase 3 catalytic subunit beta |
| NCBI Official Symbol: | PPP3CB |
| NCBI Official Synonym Symbols: | CNA2; CALNB; CALNA2; PP2Bbeta |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2B catalytic subunit beta isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform |
| UniProt Synonym Protein Names: | CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform |
| UniProt Gene Name: | PPP3CB |
| UniProt Entry Name: | PP2BB_HUMAN |
 | Western blot analysis of extracts of mouse brain, using PPP3CB antibody (CAB3629) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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