Cell Biology Antibodies 2

Anti-PPP3CA Antibody (CAB1063)

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SKU:
CAB1063
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PPP3CA Antibody
Antibody SKU:CAB1063
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human PPP3CA (NP_001124163.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, SH-SY5Y, THP-1, A-549, Mouse brain, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human PPP3CA (NP_001124163.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSEP KAID PKLS TTDR VVKA VPFP PSHR LTAK EVFD NDGK PRVD ILKA HLMK EGRL EESV ALRI ITEG ASIL RQEK NLLD IDAP VTVC GDIH GQFF DLMK LFEV GGSP ANTR YLFL GDYV DRGY FSIE CVLY LWAL KILY PKTL FLLR GNHE CRHL TEYF TFKQ ECKI KYSE RVYD ACMD AFDC LPLA ALMN QQFL CVHG GLSP EINT LDDI RKLD RFKE PPAY GPMC DILW SDPL EDFG NEKT QEHF THNT VRGC SYFY SYPA VCEF LQHN NLLS ILRA HEAQ DAGY RMYR KSQT TGFP SLIT IFSA PNYL DVYN NKAA VLKY ENNV MNIR QFNC SPHP YWLP NFMD VFTW SLPF VGEK VTEM LVNV LNIC SDDE LGSE EDGF DGAT AAAR KEVI RNKI RAIG KMAR VFSV LREE SESV LTLK GLTP TGML PSGV LSGG KQTL QSAI KGFS PQHK ITSF EEAK GLDR INER MPPR RDAM PSDA NLNS INKA LTSE TNGT DSNG SNSS NIQ
Gene ID:5530
Uniprot:Q08209
Cellular Location:Cell membrane, Nucleus, sarcolemma
Calculated MW:31kDa/51kDa/52kDa/57kDa/58kDa
Observed MW:57kDa
Synonyms:PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
Background:
UniProt Protein Function:PPP3CA: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A alpha. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. Dephosphorylates HSPB1. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively..
UniProt Protein Details:

Protein type:Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; Z disc; cytosol; calcineurin complex; sarcolemma

Molecular Function:calmodulin binding; protein dimerization activity; protein binding; enzyme binding; calmodulin-dependent protein phosphatase activity; protein heterodimerization activity; protein serine/threonine phosphatase activity; drug binding; calcium ion binding

Biological Process: regulation of synaptic transmission; positive regulation of NFAT protein import into nucleus; T cell activation; response to amphetamine; skeletal muscle fiber development; protein amino acid dephosphorylation; negative regulation of insulin secretion; calcineurin-NFAT signaling pathway; transition between fast and slow fiber; dephosphorylation; protein import into nucleus; calcium ion transport; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; regulation of excitatory postsynaptic membrane potential; multicellular organismal response to stress; G1/S transition of mitotic cell cycle

UniProt Code:Q08209
NCBI GenInfo Identifier:1352673
NCBI Gene ID:5530
NCBI Accession:Q08209.1
UniProt Related Accession:Q08209
Molecular Weight:59kDa
NCBI Full Name:Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
NCBI Synonym Full Names:protein phosphatase 3 catalytic subunit alpha
NCBI Official Symbol:PPP3CA  
NCBI Official Synonym Symbols:CALN; CCN1; CNA1; CALNA; IECEE; PPP2B; ACCIID; CALNA1; IECEE1  
NCBI Protein Information:serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
UniProt Protein Name:Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
UniProt Synonym Protein Names:CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform
UniProt Gene Name:PPP3CA  
UniProt Entry Name:PP2BA_HUMAN
Anti-PPP3CA Antibody (CAB1063)Western blot analysis of extracts of various cell lines, using PPP3CA antibody (CAB1063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-PPP3CA Antibody (CAB1063)Immunofluorescence analysis of HeLa cells using PPP3CA antibody (CAB1063). Blue: DAPI for nuclear staining.
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