Metabolism Antibodies 1

Anti-PPP1R3B Antibody (CAB14931)

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SKU:
CAB14931
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-PPP1R3B Antibody
Antibody SKU:CAB14931
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human PPP1R3B (NP_078883.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse heart, Rat brain, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human PPP1R3B (NP_078883.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MMAV DIEY RYNC MAPS LRQE RFAF KISP KPSK PLRP CIQL SSKN EASG MVAP AVQE KKVK KRVS FADN QGLA LTMV KVFS EFDD PLDM PFNI TELL DNIV SLTT AESE SFVL DFSQ PSAD YLDF RNRL QADH VCLE NCVL
Gene ID:79660
Uniprot:Q86XI6
Cellular Location:
Calculated MW:32kDa
Observed MW:33kDa
Synonyms:PPP1R3B, GL, PPP1R4, PTG
Background:This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.
UniProt Protein Function:PPP1R3B: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
UniProt Protein Details:

Protein type:Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 8p23.1

Biological Process: regulation of glycogen catabolic process

NCBI Summary:This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]
UniProt Code:Q86XI6
NCBI GenInfo Identifier:74727837
NCBI Gene ID:79660
NCBI Accession:Q86XI6.1
UniProt Secondary Accession:Q86XI6,Q9H812, B3KTV3,
UniProt Related Accession:Q86XI6
Molecular Weight:32,695 Da
NCBI Full Name:Protein phosphatase 1 regulatory subunit 3B
NCBI Synonym Full Names:protein phosphatase 1 regulatory subunit 3B
NCBI Official Symbol:PPP1R3B  
NCBI Official Synonym Symbols:GL; PTG; PPP1R4  
NCBI Protein Information:protein phosphatase 1 regulatory subunit 3B
UniProt Protein Name:Protein phosphatase 1 regulatory subunit 3B
UniProt Synonym Protein Names:Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG
Protein Family:Protein phosphatase 1 regulatory
UniProt Gene Name:PPP1R3B  
UniProt Entry Name:PPR3B_HUMAN
Anti-PPP1R3B Antibody (CAB14931)Western blot analysis of extracts of various cell lines, using PPP1R3B antibody (CAB14931) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s.
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