Cell Death Antibodies 1

Anti-PPP1R13B Antibody (CAB15411)

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SKU:
CAB15411
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-PPP1R13B Antibody
Antibody SKU:CAB15411
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human PPP1R13B (NP_056131.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human PPP1R13B (NP_056131.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MMPM ILTV FLSN NEQI LTEV PITP ETTC RDVV EFCK EPGE GSCH LAEV WRGN ERPI PFDH MMYE HLQK WGPR REEV KFFL RHED SPTE NSEQ GGRQ TQEQ RTQR NVIN VPGE KRTE NGVG NPRV ELTL SELQ DMAA RQQQ QIEN QQQM LVAK EQRL HFLK QQER RQQQ SISE NEKL QKLK ERVE AQEN KLKK IRAM RGQV DYSK IMNG NLSA EIER FSAM FQEK KQEV QTAI LRVD QLSQ QLED LKKG KLNG FQSY NGKL TGPA AVEL KRLY QELQ IRNQ LNQE QNSK LQQQ KELL NKRN MEVA MMDK RISE LRER LYGK KIQL NRVN GTSS PQSP LSTS GRVA AVGP YI
Gene ID:23368
Uniprot:Q96KQ4
Cellular Location:Cytoplasm, Nucleus
Calculated MW:119kDa
Observed MW:Refer to figures
Synonyms:PPP1R13B, ASPP1, p53BP2-like, p85
Background:This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
UniProt Protein Function:PPP1R13B: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Belongs to the ASPP family.
UniProt Protein Details:

Protein type:Apoptosis; Protein phosphatase, regulatory subunit; Tumor suppressor

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function:p53 binding; protein binding

Biological Process: negative regulation of cell cycle; regulation of apoptosis

NCBI Summary:This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
UniProt Code:Q96KQ4
NCBI GenInfo Identifier:296439434
NCBI Gene ID:23368
NCBI Accession:Q96KQ4.3
UniProt Secondary Accession:Q96KQ4,O94870, B2RMX5,
UniProt Related Accession:Q96KQ4
Molecular Weight:119,565 Da
NCBI Full Name:Apoptosis-stimulating of p53 protein 1
NCBI Synonym Full Names:protein phosphatase 1 regulatory subunit 13B
NCBI Official Symbol:PPP1R13B  
NCBI Official Synonym Symbols:p85; ASPP1; p53BP2-like  
NCBI Protein Information:apoptosis-stimulating of p53 protein 1
UniProt Protein Name:Apoptosis-stimulating of p53 protein 1
UniProt Synonym Protein Names:Protein phosphatase 1 regulatory subunit 13B
Protein Family:Apoptosis-stimulating of p53 protein
UniProt Gene Name:PPP1R13B  
UniProt Entry Name:ASPP1_HUMAN
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