Cell Death Antibodies 1
Anti-PPP1R13B Antibody (CAB15411)
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- SKU:
- CAB15411
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-PPP1R13B Antibody |
| Antibody SKU: | CAB15411 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human PPP1R13B (NP_056131.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human PPP1R13B (NP_056131.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMPM ILTV FLSN NEQI LTEV PITP ETTC RDVV EFCK EPGE GSCH LAEV WRGN ERPI PFDH MMYE HLQK WGPR REEV KFFL RHED SPTE NSEQ GGRQ TQEQ RTQR NVIN VPGE KRTE NGVG NPRV ELTL SELQ DMAA RQQQ QIEN QQQM LVAK EQRL HFLK QQER RQQQ SISE NEKL QKLK ERVE AQEN KLKK IRAM RGQV DYSK IMNG NLSA EIER FSAM FQEK KQEV QTAI LRVD QLSQ QLED LKKG KLNG FQSY NGKL TGPA AVEL KRLY QELQ IRNQ LNQE QNSK LQQQ KELL NKRN MEVA MMDK RISE LRER LYGK KIQL NRVN GTSS PQSP LSTS GRVA AVGP YI |
| Gene ID: | 23368 |
| Uniprot: | Q96KQ4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 119kDa |
| Observed MW: | Refer to figures |
| Synonyms: | PPP1R13B, ASPP1, p53BP2-like, p85 |
| Background: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. |
| UniProt Protein Function: | PPP1R13B: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Belongs to the ASPP family. |
| UniProt Protein Details: | Protein type:Apoptosis; Protein phosphatase, regulatory subunit; Tumor suppressor Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:p53 binding; protein binding Biological Process: negative regulation of cell cycle; regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96KQ4 |
| NCBI GenInfo Identifier: | 296439434 |
| NCBI Gene ID: | 23368 |
| NCBI Accession: | Q96KQ4.3 |
| UniProt Secondary Accession: | Q96KQ4,O94870, B2RMX5, |
| UniProt Related Accession: | Q96KQ4 |
| Molecular Weight: | 119,565 Da |
| NCBI Full Name: | Apoptosis-stimulating of p53 protein 1 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 13B |
| NCBI Official Symbol: | PPP1R13B |
| NCBI Official Synonym Symbols: | p85; ASPP1; p53BP2-like |
| NCBI Protein Information: | apoptosis-stimulating of p53 protein 1 |
| UniProt Protein Name: | Apoptosis-stimulating of p53 protein 1 |
| UniProt Synonym Protein Names: | Protein phosphatase 1 regulatory subunit 13B |
| Protein Family: | Apoptosis-stimulating of p53 protein |
| UniProt Gene Name: | PPP1R13B |
| UniProt Entry Name: | ASPP1_HUMAN |
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