Cell Biology Antibodies 7

Anti-PPM1K Antibody (CAB16602)

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SKU:
CAB16602
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PPM1K Antibody
Antibody SKU:CAB16602
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 183-372 of human PPM1K (NP_689755.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, Mouse heart, Mouse brain, Rat heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 183-372 of human PPM1K (NP_689755.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLTS GTTA TVAL LRDG IELV VASV GDSR AILC RKGK PMKL TIDH TPER KDEK ERIK KCGG FVAW NSLG QPHV NGRL AMTR SIGD LDLK TSGV IAEP ETKR IKLH HADD SFLV LTTD GINF MVNS QEIC DFVN QCHD PNEA AHAV TEQA IQYG TEDN STAV VVPF GAWG KYKN SEIN FSFS RSFA SSGR WA
Gene ID:152926
Uniprot:Q8N3J5
Cellular Location:Mitochondrion matrix
Calculated MW:16kDa/25kDa/40kDa
Observed MW:41kDa
Synonyms:PPM1K, BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07
Background:This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore.
UniProt Protein Function:PPM1K: Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Belongs to the PP2C family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function:metal ion binding; protein binding; protein serine/threonine phosphatase activity

Biological Process: branched chain family amino acid catabolic process; protein amino acid dephosphorylation

Disease: Maple Syrup Urine Disease, Mild Variant

NCBI Summary:This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
UniProt Code:Q8N3J5
NCBI GenInfo Identifier:74750962
NCBI Gene ID:152926
NCBI Accession:Q8N3J5.1
UniProt Secondary Accession:Q8N3J5,Q05CT5, Q49AB5, Q4W5E6, Q56AN8, Q8IUZ7, Q8IXG7 Q8ND70, Q96NT4, B2RAZ1,
UniProt Related Accession:Q8N3J5
Molecular Weight:16,759 Da
NCBI Full Name:Protein phosphatase 1K, mitochondrial
NCBI Synonym Full Names:protein phosphatase, Mg2+/Mn2+ dependent 1K
NCBI Official Symbol:PPM1K  
NCBI Official Synonym Symbols:BDP; PTMP; PP2Cm; MSUDMV; PP2Ckappa; UG0882E07  
NCBI Protein Information:protein phosphatase 1K, mitochondrial
UniProt Protein Name:Protein phosphatase 1K, mitochondrial
UniProt Synonym Protein Names:PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa
Protein Family:Protein phosphatase
UniProt Gene Name:PPM1K  
UniProt Entry Name:PPM1K_HUMAN
Anti-PPM1K Antibody (CAB16602)Western blot analysis of extracts of various cell lines, using PPM1K antibody (CAB16602) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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