Immunology Antibodies 1
Anti-PPIA Antibody (CAB0993)
- SKU:
- CAB0993
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-PPIA Antibody |
| Antibody SKU: | CAB0993 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human PPIA (NP_066953.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Jurkat, HepG2, HeLa, NIH/3T3, Mouse lung, mouse spleen, rat spleen, mouse brain, rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human PPIA (NP_066953.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVNP TVFF DIAV DGEP LGRV SFEL FADK VPKT AENF RALS TGEK GFGY KGSC FHRI IPGF MCQG GDFT RHNG TGGK SIYG EKFE DENF ILKH TGPG ILSM ANAG PNTN GSQF FICT AKTE WLDG KHVV FGKV KEGM NIVE AMER FGSR NGKT SKKI TIAD CGQL E |
| Gene ID: | 5478 |
| Uniprot: | P62937 |
| Cellular Location: | Cytoplasm, Secreted |
| Calculated MW: | 11kDa/18kDa |
| Observed MW: | 17kDa |
| Synonyms: | PPIA, CYPA, CYPH, HEL-S-69p |
| Background: | This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. |
| UniProt Protein Function: | PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; RNA-binding; Cyclophilin; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 7p13 Cellular Component: cytosol; extracellular region; extracellular space; focal adhesion; membrane; nucleus Molecular Function:peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding Biological Process: entry into host cell; leukocyte migration; positive regulation of protein secretion; positive regulation of viral genome replication; protein folding; protein peptidyl-prolyl isomerization; regulation of viral genome replication; release of virus from host; RNA-dependent DNA replication; uncoating of virus; viral envelope fusion with host membrane; viral infectious cycle; virus assembly |
| NCBI Summary: | This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62937 |
| NCBI GenInfo Identifier: | 51702775 |
| NCBI Gene ID: | 5478 |
| NCBI Accession: | P62937.2 |
| UniProt Secondary Accession: | P62937,P05092, Q3KQW3, Q567Q0, Q6IBU5, Q96IX3, Q9BRU4 Q9BTY9, Q9UC61, A8K220, |
| UniProt Related Accession: | P62937 |
| Molecular Weight: | 11,418 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase A |
| NCBI Synonym Full Names: | peptidylprolyl isomerase A |
| NCBI Official Symbol: | PPIA |
| NCBI Official Synonym Symbols: | CYPA; CYPH; HEL-S-69p |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase A |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase A |
| UniProt Synonym Protein Names: | Cyclophilin A; Cyclosporin A-binding protein; Rotamase A |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIA |
| UniProt Entry Name: | PPIA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPIA antibody (CAB0993) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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