Cell Biology Antibodies 13

Anti-PPHLN1 Antibody (CAB17706)

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SKU:
CAB17706
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PPHLN1 Antibody
Antibody SKU:CAB17706
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 195-255 of human PPHLN1 (NP_958846.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, THP-1, Mouse testis, Rat testis, Rat spleen, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 195-255 of human PPHLN1 (NP_958846.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KSDE SNLP EISE YEAG STAP LFTD QPEE PESN TTHG IELF EDSQ LTTR SKAI ASKT KEIE Q
Gene ID:51535
Uniprot:Q8NEY8
Cellular Location:
Calculated MW:
Observed MW:53kDa
Anti-PPHLN1 Antibody (CAB17706)Western blot - PPHLN1 Polyclonal Antibody (CAB17706)
Synonyms:CR, HSPC206, HSPC232, PPHLN1
Background:The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Protein Function:PPHLN1: Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm

Molecular Function:protein binding

NCBI Summary:The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NEY8
NCBI GenInfo Identifier:46396942
NCBI Gene ID:51535
NCBI Accession:Q8NEY8.2
UniProt Secondary Accession:Q8NEY8,Q86YT2, Q8IXN3, Q8TB09, Q96NB9, Q9NXL4, Q9P0P6 Q9P0R9, E9PAX8,
UniProt Related Accession:Q8NEY8
Molecular Weight:40,319 Da
NCBI Full Name:Periphilin-1
NCBI Synonym Full Names:periphilin 1
NCBI Official Symbol:PPHLN1  
NCBI Official Synonym Symbols:CR; HSPC206; HSPC232  
NCBI Protein Information:periphilin-1
UniProt Protein Name:Periphilin-1
UniProt Synonym Protein Names:CDC7 expression repressor
Protein Family:Periphilin
UniProt Gene Name:PPHLN1  
UniProt Entry Name:PPHLN_HUMAN
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