Cell Biology Antibodies 12

Anti-PPFIA3 Antibody (CAB8714)

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SKU:
CAB8714
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PPFIA3 Antibody
Antibody SKU:CAB8714
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 460-590 of human PPFIA3 (NP_003651.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, HeLa, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 460-590 of human PPFIA3 (NP_003651.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NSLS EEIA NMKK LQDE LLLN KEQL LAEM ERMQ MEID QLRG RPPS SYSR SLPG SALE LRYS QAPT LPSG AHLD PYVA GSGR AGKR GRWS GVKE EPSK DWER SAPA GSIP PPFP GELD GSDE EEAE GMFG AEL
Gene ID:8541
Uniprot:O75145
Cellular Location:Cell surface, Cytoplasm
Calculated MW:132kDa/133kDa
Observed MW:133kDa
Synonyms:PPFIA3, LPNA3
Background:The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones.
UniProt Protein Function:May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
NCBI Summary:The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]
UniProt Code:O75145
NCBI GenInfo Identifier:32189362
NCBI Gene ID:8541
NCBI Accession:NP_003651.1
UniProt Secondary Accession:O75145,Q3MJA0, Q9H8B5, Q9UEW4, A8K142,
UniProt Related Accession:O75145
Molecular Weight:132,365 Da
NCBI Full Name:liprin-alpha-3
NCBI Synonym Full Names:PTPRF interacting protein alpha 3
NCBI Official Symbol:PPFIA3  
NCBI Official Synonym Symbols:LPNA3  
NCBI Protein Information:liprin-alpha-3
UniProt Protein Name:Liprin-alpha-3
UniProt Synonym Protein Names:Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3; PTPRF-interacting protein alpha-3
Protein Family:Liprin
UniProt Gene Name:PPFIA3  
Anti-PPFIA3 Polyclonal Antibody (CAB8714)Western blot analysis of extracts of various cell lines, using PPFIA3 antibody (CAB8714) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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