Cell Biology Antibodies 7

Anti-PPBP Antibody (CAB1925)

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SKU:
CAB1925
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PPBP Antibody
Antibody SKU:CAB1925
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 31-128 of human PPBP (NP_002695.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:Human serum
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 31-128 of human PPBP (NP_002695.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TALA SSTK GQTK RNLA KGKE ESLD SDLY AELR CMCI KTTS GIHP KNIQ SLEV IGKG THCN QVEV IATL KDGR KICL DPDA PRIK KIVQ KKLA GDES AD
Gene ID:5473
Uniprot:P02775
Cellular Location:Secreted
Calculated MW:13kDa
Observed MW:14kDa
Synonyms:PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
Background:The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity.
UniProt Protein Function:PPBP: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 4q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function:growth factor activity; chemokine activity; CXCR chemokine receptor binding; glucose transmembrane transporter activity

Biological Process: platelet activation; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; glucose transport; leukocyte migration during inflammatory response; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; platelet degranulation; positive regulation of cell division; defense response to bacterium; immune response; blood coagulation; inflammatory response

NCBI Summary:The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. [provided by RefSeq, May 2010]
UniProt Code:P02775
NCBI GenInfo Identifier:129874
NCBI Gene ID:5473
NCBI Accession:P02775.3
UniProt Secondary Accession:P02775,Q6IBJ8, B2R5F3,
UniProt Related Accession:P02775,AAB46877
Molecular Weight:13,894 Da
NCBI Full Name:Platelet basic protein
NCBI Synonym Full Names:pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
NCBI Official Symbol:PPBP  
NCBI Official Synonym Symbols:PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III  
NCBI Protein Information:platelet basic protein; thrombocidin 1; thrombocidin 2; beta-thromboglobulin; CXC chemokine ligand 7; C-X-C motif chemokine 7; thromboglobulin, beta-1; small inducible cytokine B7; small-inducible cytokine B7; leukocyte-derived growth factor; low-affinity platelet factor IV; neutrophil-activating peptide 2; neutrophil-activating peptide-2; macrophage-derived growth factor; connective tissue-activating peptide III; small inducible cytokine subfamily B, member 7
UniProt Protein Name:Platelet basic protein
UniProt Synonym Protein Names:C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF; Small-inducible cytokine B7Cleaved into the following 10 chains:Connective tissue-activating peptide III; CTAP-III; Alternative name(s):; LA-PF4; Low-affinity platelet factor IV
Protein Family:Placenta growth factor
UniProt Gene Name:PPBP  
UniProt Entry Name:CXCL7_HUMAN
Anti-PPBP Antibody (CAB1925)Western blot analysis of extracts of human serum, using PPBP antibody (CAB1925) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min.
Anti-PPBP Antibody (CAB1925)Immunohistochemistry of paraffin-embedded human liver cancer using PPBP antibody (CAB1925) at dilution of 1:100 (40x lens).
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