Epigenetics & Nuclear Signaling Antibodies 3

Anti-PPARGC1B Antibody (CAB17257)

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SKU:
CAB17257
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-PPARGC1B Antibody
Antibody SKU:CAB17257
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 850-950 of human PPARGC1B (NP_001166170.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, MCF7, mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 850-950 of human PPARGC1B (NP_001166170.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SSRE LKRR FEVF GEIE ECEV LTRN RRGE KYGF ITYR CSEH AALS LTKG AALR KRNE PSFQ LSYG GLRH FCWP RYTD YDSN SEEA LPAS GKSK YEAM DFDS L
Gene ID:133522
Uniprot:Q86YN6
Cellular Location:
Calculated MW:106kDa/108kDa/110kDa/112kDa/113kDa
Observed MW:113kDa
Synonyms:PPARGC1B, ERRL1, PERC, PGC-1(beta), PGC1B, PPARGC1B
Background:The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene.
NCBI Summary:The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Code:Q86YN6
NCBI GenInfo Identifier:289577090
NCBI Gene ID:133522
NCBI Accession:NP_001166169.1
UniProt Related Accession:Q86YN6
Molecular Weight:113kDa
NCBI Full Name:peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2
NCBI Synonym Full Names:PPARG coactivator 1 beta
NCBI Official Symbol:PPARGC1B  
NCBI Official Synonym Symbols:PERC; ERRL1; PGC1B; PGC-1(beta)  
NCBI Protein Information:peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Protein Name:Peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Synonym Protein Names:PGC-1-related estrogen receptor alpha coactivator
UniProt Gene Name:PPARGC1B  
UniProt Entry Name:PRGC2_HUMAN
Anti-PPARGC1B Antibody (CAB17257)Western blot analysis of extracts of various cell line, using PPARGC1B antibody (CAB17257) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min.
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