Metabolism Antibodies 2
Anti-PPAP2A Antibody (CAB3062)
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- SKU:
- CAB3062
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PPAP2A Antibody |
| Antibody SKU: | CAB3062 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PPAP2A (NP_003702.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, 293T, A-549, HepG2, SW480, Mouse lung, Mouse heart, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PPAP2A (NP_003702.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MFDK TRLP YVAL DVLC VLLA GLPF AILT SRHT PFQR GVFC NDES IKYP YKED TIPY ALLG GIII PFSI IVII LGET LSVY CNLL HSNS FIRN NYIA TIYK |
| Gene ID: | 8611 |
| Uniprot: | O14494 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 32kDa |
| Observed MW: | 32kDa |
| Synonyms: | PLPP1, LLP1a, LPP1, PAP-2a, PAP2, PPAP2A |
| Background: | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. |
| UniProt Protein Function: | PPAP2A: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Lipid Metabolism - sphingolipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Membrane protein, multi-pass; Lipid Metabolism - glycerolipid; Phosphatase (non-protein); EC 3.1.3.4 Chromosomal Location of Human Ortholog: 5q11 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:phosphatidate phosphatase activity Biological Process: steroid hormone receptor signaling pathway; negative regulation of cell proliferation; regulation of lipid metabolic process; sphingolipid metabolic process; sphingolipid biosynthetic process; germ cell migration; protein kinase C activation; androgen receptor signaling pathway; lipid metabolic process; protein amino acid dephosphorylation; phospholipid dephosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
| UniProt Code: | O14494 |
| NCBI GenInfo Identifier: | 45477007 |
| NCBI Gene ID: | 8611 |
| NCBI Accession: | O14494.1 |
| UniProt Related Accession: | O14494 |
| Molecular Weight: | |
| NCBI Full Name: | Phospholipid phosphatase 1 |
| NCBI Synonym Full Names: | phospholipid phosphatase 1 |
| NCBI Official Symbol: | PLPP1 |
| NCBI Official Synonym Symbols: | LPP1; PAP2; LLP1a; PAP-2a; PPAP2A |
| NCBI Protein Information: | phospholipid phosphatase 1 |
| UniProt Protein Name: | Lipid phosphate phosphohydrolase 1 |
| UniProt Synonym Protein Names: | PAP2-alpha; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; PAP-2a; PAP2a |
| UniProt Gene Name: | PPAP2A |
| UniProt Entry Name: | LPP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPAP2A Rabbit pAb (CAB3062) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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