Epigenetics & Nuclear Signaling Antibodies 1
Anti-POU2F3 Antibody (CAB10054)
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- SKU:
- CAB10054
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-POU2F3 Antibody |
| Antibody SKU: | CAB10054 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human POU2F3 (NP_055167.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver, Mouse heart, Mouse stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human POU2F3 (NP_055167.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVNL ESMH TDIK MSGD VADS TDAR STLS QVEP GNDR NGLD FNRQ IKTE DLSD SLQQ TLSH RPCH LSQG PAMM SGNQ MSGL NASP CQDM ASLH PLQQ LVLV PGHL QSVS QFLL SQTQ PGQQ GLQP NLLP FPQQ QSGL LLPQ TGPG LASQ AFGH PGLP GSSL EPHL EASQ HLPV PKHL PSSG |
| Gene ID: | 25833 |
| Uniprot: | Q9UKI9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 46kDa/47kDa |
| Observed MW: | 47kDa |
| Synonyms: | POU2F3, Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a |
| Background: | This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen. |
| NCBI Summary: | This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9UKI9 |
| NCBI GenInfo Identifier: | 311033416 |
| NCBI Gene ID: | 25833 |
| NCBI Accession: | Q9UKI9.3 |
| UniProt Secondary Accession: | Q9UKI9,Q3MIY3, Q9UKR7, Q9Y504, A8K7H8, B4DY07, F5GWW6 |
| UniProt Related Accession: | Q9UKI9 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | POU domain, class 2, transcription factor 3 |
| NCBI Synonym Full Names: | POU class 2 homeobox 3 |
| NCBI Official Symbol: | POU2F3 |
| NCBI Official Synonym Symbols: | PLA1; OCT11; PLA-1; Epoc-1; OCT-11; OTF-11; Skn-1a |
| NCBI Protein Information: | POU domain, class 2, transcription factor 3 |
| UniProt Protein Name: | POU domain, class 2, transcription factor 3 |
| UniProt Synonym Protein Names: | Octamer-binding protein 11; Oct-11; Octamer-binding transcription factor 11; OTF-11; Transcription factor PLA-1; Transcription factor Skn-1 |
| Protein Family: | POU domain, class 2, transcription factor |
| UniProt Gene Name: | POU2F3 |
 | Western blot analysis of extracts of various cell lines, using POU2F3 Antibody (CAB10054) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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