Epigenetics & Nuclear Signaling Antibodies 3
Anti-POU2F1 Antibody (CAB1682)
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- SKU:
- CAB1682
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-POU2F1 Antibody |
| Antibody SKU: | CAB1682 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-290 of human POU2F1 (NP_001185712.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-290 of human POU2F1 (NP_001185712.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NPSE TSKP SMES GDGN TGTQ TNGL DFQK QPVP VGGA ISTA QAQA FLGH LHQV QLAG TSLQ AAAQ SLNV QSKS NEES GDSQ QPSQ PSQQ PSVQ AAIP QTQL MLAG GQIT GLTL TPAQ QQLL LQQA QAQA QLLA AAVQ QHSA SQQH SAAG ATIS ASAA TPMT QIPL SQPI QIAQ DLQQ LQQL QQQN LNLQ QFVL VHPT TNLQ PAQF IISQ TPQG QQGL LQAQ NLLT QLPQ QSQA NLLQ SQPS ITLT SQPA TPTR TIAA TPIQ TLPQ SQST PKRI DTPS |
| Gene ID: | 5451 |
| Uniprot: | P14859 |
| Cellular Location: | Nucleus |
| Calculated MW: | 68kDa/72kDa/76kDa/77kDa/78kDa |
| Observed MW: | 90kDa |
| Synonyms: | POU2F1, OCT1, OTF1, oct-1B |
| Background: |
| UniProt Protein Function: | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
| NCBI Summary: | The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010] |
| UniProt Code: | P14859 |
| NCBI GenInfo Identifier: | 28202257 |
| NCBI Gene ID: | 5451 |
| NCBI Accession: | P14859.2 |
| UniProt Secondary Accession: | P14859,Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1, B1AL91, B1AL93 B4E029, J3KP77, |
| UniProt Related Accession: | P14859 |
| Molecular Weight: | 72,082 Da |
| NCBI Full Name: | POU domain, class 2, transcription factor 1 |
| NCBI Synonym Full Names: | POU class 2 homeobox 1 |
| NCBI Official Symbol: | POU2F1 |
| NCBI Official Synonym Symbols: | OCT1; OTF1; oct-1B |
| NCBI Protein Information: | POU domain, class 2, transcription factor 1 |
| UniProt Protein Name: | POU domain, class 2, transcription factor 1 |
| UniProt Synonym Protein Names: | NF-A1; Octamer-binding protein 1; Oct-1; Octamer-binding transcription factor 1; OTF-1 |
| Protein Family: | POU domain, class 2, transcription factor |
| UniProt Gene Name: | POU2F1 |
| UniProt Entry Name: | PO2F1_HUMAN |
 | Western blot analysis of extracts of rat kidney, using POU2F1 antibody (CAB1682) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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