Cell Biology Antibodies 8
Anti-POSTN Antibody (CAB2003)
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- SKU:
- CAB2003
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-POSTN Antibody |
| Antibody SKU: | CAB2003 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CMEK GSKQ GRNG AIHI FREI IKPA EKSL HEKL KQDK RFST FLSL LEAA DLKE LLTQ PGDW TLFV PTND AFKG MTSE EKEI LIRD KNAL QNII LYHL TPGV FIGK GFEP GVTN ILKT TQGS KIFL KEVN DTLL VNEL KSKE SDIM TTNG VIHV VDKL LYPA DTPV GNDQ LLEI LNKL IKYI QIKF VRGS TFKE IPVT VYKP IIKK YTKI IDGV PVEI TEKE TREE RIIT GPEI KYTR ISTG GGET EETL KKLL QEDT PVRK LQAN KKVQ GSRR RLRE GRSQ |
| Gene ID: | 10631 |
| Uniprot: | Q15063 |
| Cellular Location: | Golgi apparatus, Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 80kDa/83kDa/87kDa/90kDa/93kDa |
| Observed MW: | Refer to figures |
| Synonyms: | POSTN, OSF-2, OSF2, PDLPOSTN, PN, periostin |
| Background: | This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 13q13.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; trans-Golgi network Molecular Function:heparin binding; protein binding; cell adhesion molecule binding Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development |
| NCBI Summary: | This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q15063 |
| NCBI GenInfo Identifier: | 93138709 |
| NCBI Gene ID: | 10631 |
| NCBI Accession: | Q15063.2 |
| UniProt Secondary Accession: | Q15063,Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9, B1ALD8 C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628, |
| UniProt Related Accession: | Q15063 |
| Molecular Weight: | 80,357 Da |
| NCBI Full Name: | Periostin |
| NCBI Synonym Full Names: | periostin, osteoblast specific factor |
| NCBI Official Symbol: | POSTN |
| NCBI Official Synonym Symbols: | PN; OSF2; OSF-2; PDLPOSTN; periostin |
| NCBI Protein Information: | periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like) |
| UniProt Protein Name: | Periostin |
| UniProt Synonym Protein Names: | Osteoblast-specific factor 2; OSF-2 |
| Protein Family: | Periostin |
| UniProt Gene Name: | POSTN |
| UniProt Entry Name: | POSTN_HUMAN |
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