Cell Biology Antibodies 5

Anti-POSTN Antibody (CAB14556)

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SKU:
CAB14556
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-POSTN Antibody
Antibody SKU:CAB14556
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CMEK GSKQ GRNG AIHI FREI IKPA EKSL HEKL KQDK RFST FLSL LEAA DLKE LLTQ PGDW TLFV PTND AFKG MTSE EKEI LIRD KNAL QNII LYHL TPGV FIGK GFEP GVTN ILKT TQGS KIFL KEVN DTLL VNEL KSKE SDIM TTNG VIHV VDKL LYPA DTPV GNDQ LLEI LNKL IKYI QIKF VRGS TFKE IPVT VYKP IIKK YTKI IDGV PVEI TEKE TREE RIIT GPEI KYTR ISTG GGET EETL KKLL QEDT PVRK LQAN KKVQ GSRR RLRE GRSQ
Gene ID:10631
Uniprot:Q15063
Cellular Location:Golgi apparatus, Secreted, extracellular matrix, extracellular space
Calculated MW:80kDa/83kDa/87kDa/90kDa/93kDa
Observed MW:93kDa
Synonyms:POSTN, OSF-2, OSF2, PDLPOSTN, PN, periostin
Background:This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; trans-Golgi network

Molecular Function:heparin binding; protein binding; cell adhesion molecule binding

Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development

NCBI Summary:This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
UniProt Code:Q15063
NCBI GenInfo Identifier:93138709
NCBI Gene ID:10631
NCBI Accession:Q15063.2
UniProt Secondary Accession:Q15063,Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9, B1ALD8 C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628,
UniProt Related Accession:Q15063
Molecular Weight:80,357 Da
NCBI Full Name:Periostin
NCBI Synonym Full Names:periostin, osteoblast specific factor
NCBI Official Symbol:POSTN  
NCBI Official Synonym Symbols:PN; OSF2; OSF-2; PDLPOSTN; periostin  
NCBI Protein Information:periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like)
UniProt Protein Name:Periostin
UniProt Synonym Protein Names:Osteoblast-specific factor 2; OSF-2
Protein Family:Periostin
UniProt Gene Name:POSTN  
UniProt Entry Name:POSTN_HUMAN
Anti-POSTN Antibody (CAB14556)Western blot analysis of extracts of Rat lung, using POSTN antibody (CAB14556) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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