Signal Transduction Antibodies 2
Anti-PON3 Antibody (CAB16418)
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- SKU:
- CAB16418
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-PON3 Antibody |
| Antibody SKU: | CAB16418 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Jurkat, HepG2 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PON3 (NP_000931.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HDNW DLTQ LKVI QLGT LVDN LTVD PATG DILA GCHP NPMK LLNY NPED PPGS EVLR IQNV LSEK PRVS TVYA NNGS VLQG TSVA SVYH GKIL IGTV FHKT L |
| Gene ID: | 5446 |
| Uniprot: | Q15166 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 39kDa |
| Observed MW: | 39kDa |
| Synonyms: | PON3 |
| Background: | This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. |
| UniProt Protein Function: | PON3: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. Belongs to the paraoxonase family. |
| UniProt Protein Details: | Protein type:EC 3.1.1.81; Secreted; EC 3.1.1.2; Hydrolase; Secreted, signal peptide; EC 3.1.8.1 Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: extracellular space Molecular Function:arylesterase activity; protein homodimerization activity Biological Process: aromatic compound catabolic process; carboxylic acid catabolic process; response to toxin |
| NCBI Summary: | This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15166 |
| NCBI GenInfo Identifier: | 50403778 |
| NCBI Gene ID: | 5446 |
| NCBI Accession: | Q15166.3 |
| UniProt Secondary Accession: | Q15166,O75855, O76060, Q6IRU9, Q8IX97, Q9BZH9, A4D1H8 |
| UniProt Related Accession: | Q15166 |
| Molecular Weight: | 39,607 Da |
| NCBI Full Name: | Serum paraoxonase/lactonase 3 |
| NCBI Synonym Full Names: | paraoxonase 3 |
| NCBI Official Symbol: | PON3 |
| NCBI Protein Information: | serum paraoxonase/lactonase 3 |
| UniProt Protein Name: | Serum paraoxonase/lactonase 3 |
| Protein Family: | Serum paraoxonase/lactonase |
| UniProt Gene Name: | PON3 |
| UniProt Entry Name: | PON3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PON3 Rabbit pAb (CAB16418) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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