Cell Biology Antibodies 4
Anti-PON2 Antibody (CAB14048)
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- SKU:
- CAB14048
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PON2 Antibody |
| Antibody SKU: | CAB14048 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PON2 (NP_000296.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: | HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PON2 (NP_000296.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGRL VAVG LLGI ALAL LGER LLAL RNRL KASR EVES VDLP HCHL IKGI EAGS EDID ILPN GLAF FSVG LKFP GLHS FAPD KPGG ILMM DLKE EKPR AREL RISR GFDL ASFN PHGI STFI DNDD TVYL FVVN HPEF KNTV EIFK FEEA ENSL LHLK TVKH ELLP SVND ITAV GPAH FYAT NDHY FSDP FLKY LETY LNLH WANV VYYS PN |
| Gene ID: | 5445 |
| Uniprot: | Q15165 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 37kDa/39kDa |
| Observed MW: | 40kDa |
| Synonyms: | PON2 |
| Background: | This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.1.81; Hydrolase; EC 3.1.1.2; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: mitochondrion; lysosome; plasma membrane; extracellular region; nucleus Molecular Function:identical protein binding; arylesterase activity; metal ion binding Biological Process: response to oxidative stress; aromatic compound catabolic process |
| UniProt Code: | Q15165 |
| NCBI GenInfo Identifier: | 325511384 |
| NCBI Gene ID: | |
| NCBI Accession: | Q15165.3 |
| Molecular Weight: | |
| NCBI Full Name: | Serum paraoxonase/arylesterase 2 |
| UniProt Protein Name: | Serum paraoxonase/arylesterase 2 |
| UniProt Synonym Protein Names: | Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2 |
| Protein Family: | Serum paraoxonase/arylesterase |
| UniProt Gene Name: | PON2 |
| UniProt Entry Name: | PON2_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using PON2 Rabbit pAb (CAB14048) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
 | Immunohistochemistry of paraffin-embedded rat lung using PON2 Antibody (CAB14048) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using PON2 antibody (CAB14048). Blue: DAPI for nuclear staining. |
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