| UniProt Protein Function: | POLR2L: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. |
| UniProt Protein Details: | Protein type:EC 2.7.7.6; Transcription initiation complex; Transferase; Nucleotide Metabolism - pyrimidine; DNA-binding; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 11p15 Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; DNA-directed RNA polymerase II, core complex; nucleus; cytosol; DNA-directed RNA polymerase I complex Molecular Function:DNA binding; zinc ion binding; DNA-directed RNA polymerase activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase I promoter; termination of RNA polymerase III transcription; viral reproduction; positive regulation of viral transcription; somatic stem cell maintenance; RNA splicing; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; termination of RNA polymerase I transcription; DNA repair; regulation of gene expression, epigenetic; nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase III promoter; mRNA capping; nucleotide-excision repair; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; positive regulation of interferon type I production; innate immune response; gene expression; transcription initiation from RNA polymerase I promoter; RNA elongation from RNA polymerase III promoter |
| NCBI Summary: | This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62875 |
| NCBI GenInfo Identifier: | 51338657 |
| NCBI Gene ID: | 5441 |
| NCBI Accession: | P62875.1 |
| UniProt Secondary Accession: | P62875,P52436, Q6FHX3, |
| UniProt Related Accession: | P62875 |
| Molecular Weight: | 67 |
| NCBI Full Name: | DNA-directed RNA polymerases I, II, and III subunit RPABC5 |
| NCBI Synonym Full Names: | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa |
| NCBI Official Symbol: | POLR2L |
| NCBI Official Synonym Symbols: | RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; RPB10beta |
| NCBI Protein Information: | DNA-directed RNA polymerases I, II, and III subunit RPABC5; RPB10 homolog; RNA polymerase II 7.6 kDa subunit; DNA-directed RNA polymerase III subunit L; RNA polymerases I, II, and III subunit ABC5 |
| UniProt Protein Name: | DNA-directed RNA polymerases I, II, and III subunit RPABC5 |
| UniProt Synonym Protein Names: | DNA-directed RNA polymerase III subunit L; RNA polymerase II 7.6 kDa subunit; RPB7.6; RPB10 homolog |
| UniProt Gene Name: | POLR2L |
| UniProt Entry Name: | RPAB5_HUMAN |
