| UniProt Protein Function: | POLR2K: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. |
| UniProt Protein Details: | Protein type:DNA repair, damage; RNA processing Chromosomal Location of Human Ortholog: 8q22.2 Cellular Component: cytosol; DNA-directed RNA polymerase I complex; DNA-directed RNA polymerase II, core complex; DNA-directed RNA polymerase III complex; nucleoplasm; nucleus Molecular Function:zinc ion binding Biological Process: fibroblast growth factor receptor signaling pathway; gene expression; mRNA capping; nuclear mRNA splicing, via spliceosome; positive regulation of gene expression, epigenetic; positive regulation of interferon type I production; positive regulation of viral transcription; regulation of transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; RNA elongation from RNA polymerase II promoter; RNA-mediated gene silencing; snRNA transcription from RNA polymerase II promoter; somatic stem cell maintenance; termination of RNA polymerase I transcription; transcription from RNA polymerase II promoter; transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair |
| NCBI Summary: | This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53803 |
| NCBI GenInfo Identifier: | 4826924 |
| NCBI Gene ID: | 5440 |
| NCBI Accession: | NP_005025.1 |
| UniProt Secondary Accession: | P53803,Q6IBD4, |
| UniProt Related Accession: | P53803 |
| Molecular Weight: | 7,004 Da |
| NCBI Full Name: | DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
| NCBI Synonym Full Names: | RNA polymerase II subunit K |
| NCBI Official Symbol: | POLR2K |
| NCBI Official Synonym Symbols: | RPB12; RPABC4; RPB7.0; hRPB7.0; hsRPB10a; RPB10alpha; ABC10-alpha |
| NCBI Protein Information: | DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
| UniProt Protein Name: | DNA-directed RNA polymerases I, II, and III subunit RPABC4 |
| UniProt Synonym Protein Names: | ABC10-alpha; DNA-directed RNA polymerase II subunit K; RNA polymerase II 7.0 kDa subunit; RPB7.0; RPB10alpha |
| UniProt Gene Name: | POLR2K |
