Cell Biology Antibodies 11
Anti-POC1B Antibody (CAB7616)
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- SKU:
- CAB7616
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-POC1B Antibody |
| Antibody SKU: | CAB7616 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 299-478 of human POC1B (NP_758440.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 299-478 of human POC1B (NP_758440.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TNFD ELHC KGLT KRNL KRLH FDSP PHLL DIYP RTPH PHEE KVET VEIN PKLE VIDL QIST PPVM DILS FDST TTTE TSGR TLPD KGEE ACGY FLNP SLMS PECL PTTT KKKT EDMS DLPC ESQR SIPL AVTD ALEH IMEQ LNVL TQTV SILE QRLT LTED KLKD CLEN QQKL FSAV QQKS |
| Gene ID: | 282809 |
| Uniprot: | Q8TC44 |
| Cellular Location: | Cytoplasm, centriole, centrosome, cilium basal body, cytoskeleton, microtubule organizing center, spindle pole |
| Calculated MW: | 49kDa/53kDa |
| Observed MW: | 54kDa |
| Synonyms: | POC1B, CORD20, PIX1, TUWD12, WDR51B |
| Background: | POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | WDR51B: Required for ciliogenesis. Belongs to the WD repeat POC1 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q21.33 Cellular Component: centriole; centrosome; spindle pole Molecular Function:protein binding Biological Process: cell proliferation; cilium biogenesis; retinal homeostasis Disease: Cone-rod Dystrophy 20 |
| NCBI Summary: | POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q8TC44 |
| NCBI GenInfo Identifier: | 74762610 |
| NCBI Gene ID: | 282809 |
| NCBI Accession: | Q8TC44.1 |
| UniProt Secondary Accession: | Q8TC44,G3V1X0, |
| UniProt Related Accession: | Q8TC44 |
| Molecular Weight: | 49,104 Da |
| NCBI Full Name: | POC1 centriolar protein homolog B |
| NCBI Synonym Full Names: | POC1 centriolar protein B |
| NCBI Official Symbol: | POC1B |
| NCBI Official Synonym Symbols: | PIX1; CORD20; TUWD12; WDR51B |
| NCBI Protein Information: | POC1 centriolar protein homolog B |
| UniProt Protein Name: | POC1 centriolar protein homolog B |
| UniProt Synonym Protein Names: | Pix1; Proteome of centriole protein 1B; WD repeat-containing protein 51B |
| Protein Family: | POC1 centriolar protein |
| UniProt Gene Name: | POC1B |
| UniProt Entry Name: | POC1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using POC1B antibody (CAB7616) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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