Epigenetics & Nuclear Signaling Antibodies 2
Anti-PNRC2 Antibody (CAB16549)
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- SKU:
- CAB16549
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PNRC2 Antibody |
| Antibody SKU: | CAB16549 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGGG ERYN IPAP QSRN VSKN QQQL NRQK TKEQ NSQM KIVH KKKE RGHG YNSS AAAW QAMQ NGGK NKNF PNNQ SWNS SLSG PRLL FKSQ ANQN YAGA KFSE |
| Gene ID: | 55629 |
| Uniprot: | Q9NPJ4 |
| Cellular Location: | Cytoplasm, Nucleus, P-body |
| Calculated MW: | 13kDa/15kDa |
| Observed MW: | 16kDa |
| Synonyms: | PNRC2 |
| Background: |
| UniProt Protein Function: | PNRC2: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. Belongs to the PNRC family. PNRC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: nucleus Molecular Function:protein binding Biological Process: deadenylation-independent decapping; mRNA catabolic process, nonsense-mediated decay; regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| UniProt Code: | Q9NPJ4 |
| NCBI GenInfo Identifier: | 8923295 |
| NCBI Gene ID: | 55629 |
| NCBI Accession: | NP_060231.1 |
| UniProt Secondary Accession: | Q9NPJ4,B4DU72, |
| UniProt Related Accession: | Q9NPJ4 |
| Molecular Weight: | 13,471 Da |
| NCBI Full Name: | proline-rich nuclear receptor coactivator 2 |
| NCBI Synonym Full Names: | proline rich nuclear receptor coactivator 2 |
| NCBI Official Symbol: | PNRC2 |
| NCBI Protein Information: | proline-rich nuclear receptor coactivator 2 |
| UniProt Protein Name: | Proline-rich nuclear receptor coactivator 2 |
| Protein Family: | Proline-rich nuclear receptor coactivator |
| UniProt Gene Name: | PNRC2 |
| UniProt Entry Name: | PNRC2_HUMAN |
 | Western blot analysis of extracts of mouse lung, using PNRC2 antibody (CAB16549) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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