Cell Biology Antibodies 10
Anti-PNOC Antibody (CAB6395)
(No reviews yet)
Write a Review
- SKU:
- CAB6395
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PNOC Antibody |
| Antibody SKU: | CAB6395 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-176 of human PNOC (NP_006219.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-176 of human PNOC (NP_006219.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SCQR DCLT CQEK LHPA LDSF DLEV CILE CEEK VFPS PLWT PCTK VMAR SSWQ LSPA APEH VAAA LYQP RASE MQHL RRMP RVRS LFQE QEEP EPGM EEAG EMEQ KQLQ KRFG GFTG ARKS ARKL ANQK RFSE FMRQ YLVL SMQS SQRR RTLH QNGN V |
| Gene ID: | 5368 |
| Uniprot: | Q13519 |
| Cellular Location: | Secreted |
| Calculated MW: | 13kDa/20kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | PNOC, N/OFQ, NOP, OFQ, PPNOC, ppN/OFQ |
| Background: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. |
| UniProt Protein Function: | PNOC: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Belongs to the opioid neuropeptide precursor family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region Molecular Function:neuropeptide hormone activity; protein binding; opioid peptide activity Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; signal transduction |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q13519 |
| NCBI GenInfo Identifier: | 2494348 |
| NCBI Gene ID: | 5368 |
| NCBI Accession: | Q13519.1 |
| UniProt Related Accession: | Q13519 |
| Molecular Weight: | 13kDa; 20kDa |
| NCBI Full Name: | Prepronociceptin |
| NCBI Synonym Full Names: | prepronociceptin |
| NCBI Official Symbol: | PNOC |
| NCBI Official Synonym Symbols: | NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ |
| NCBI Protein Information: | prepronociceptin |
| UniProt Protein Name: | Prepronociceptin |
| UniProt Synonym Protein Names: | Orphanin FQ; PPNOC |
| Protein Family: | Prepronociceptin |
| UniProt Gene Name: | PNOC |
| UniProt Entry Name: | PNOC_HUMAN |
 | Immunofluorescence analysis of U2OS cells using PNOC antibody (CAB6395). Blue: DAPI for nuclear staining. |
View AllClose
Related Products
