Epigenetics & Nuclear Signaling Antibodies 4

Anti-PNKD Antibody (CAB8203)

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SKU:
CAB8203
Product Type:
Antibody
Applications:
WB
Applications:
IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:PNKD Rabbit Polyclonal Antibody
Antibody SKU:CAB8203
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:A-549, 22Rv1, THP-1, Mouse brain, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAV VAAT ALKG RGAR NARV LRGI LAGA TANK ASHN RTRA LQSH SSPE GKEE PEPL SPEL EYIP RKRG KNPM KAVG LAWY SLYT RTWL GYLF YRQQ LRRA RNRY PKGH SKTQ PRLF NGVK VLPI PVLS DNYS YLII DTQA QLAV AVDP SDPR AVQA SIEK EGVT LVAI LCTH KHWD HSGG NRDL SRRH RDCR VYGS PQDG IPYL THPL CHQD VVSV GRLQ IRAL ATPG HTQG HLVY LLDG EPYK GPSC LFSG DLLF LSGC GRTF EGNA ET
Gene ID:25953
Uniprot:Q8N490
Cellular Location:Cytoplasm, Membrane, Mitochondrion, Nucleus, Peripheral membrane protein
Calculated MW:15kDa/36kDa/40kDa/42kDa
Observed MW:43kDa
Synonyms:PNKD, BRP17, DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR1, PDC, PKND1, TAHCCP2
Background:This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.
NCBI Summary:This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Code:Q8N490
NCBI GenInfo Identifier:158563846
NCBI Gene ID:25953
NCBI Accession:Q8N490.2
UniProt Secondary Accession:Q8N490,Q96A48, Q9BU26, Q9NSX4, Q9ULN6, Q9Y4T1, A8K1F2
UniProt Related Accession:Q8N490
Molecular Weight:36,849 Da
NCBI Full Name:Probable hydrolase PNKD
NCBI Synonym Full Names:paroxysmal nonkinesigenic dyskinesia
NCBI Official Symbol:PNKD  
NCBI Official Synonym Symbols:MR1; PDC; DYT8; FPD1; MR-1; BRP17; PKND1; FKSG19; TAHCCP2; KIPP1184  
NCBI Protein Information:probable hydrolase PNKD
UniProt Protein Name:Probable hydrolase PNKD
UniProt Synonym Protein Names:Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2
Protein Family:Probable hydrolase
UniProt Gene Name:PNKD  
UniProt Entry Name:PNKD_HUMAN
Anti-PNKD Polyclonal Antibody (CAB8203)Western blot analysis of extracts of various cell lines, using PNKD antibody (CAB8203) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PNKD Polyclonal Antibody (CAB8203)Immunofluorescence analysis of U2OS cells using PNKD antibody (CAB8203) at dilution of 1:100. Blue: DAPI for nuclear staining.
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