Anti-PMEL Antibody (CAB5384)
- SKU:
- CAB5384
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PMEL
- Synonyms:
- D12S53E
- Synonyms:
- ME20
- Synonyms:
- ME20-M
- Synonyms:
- ME20M
- Synonyms:
- P1
- Synonyms:
- P100
- Synonyms:
- PMEL17
- Synonyms:
- SI
- Synonyms:
- SIL
- Synonyms:
- SILV
- Synonyms:
- gp100
Description
| Product Name: | PMEL Rabbit pAb |
| Product Code: | CAB5384 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PMEL, D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KVPR NQDW LGVS RQLR TKAW NRQL YPEW TEAQ RLDC WRGG QVSL KVSN DGPT LIGA NASF SIAL NFPG SQKV LPDG QVIW VNNT IING SQVW GGQP VYPQ ETDD ACIF PDGG PCPS GSWS QKRS FVYV WKTW GQYW QVLG GPVS GLSI GTGR AMLG THTM EVTV YHRR GSRS YVPL AHSS SAFT ITDQ VPFS VSVS QLRA LDGG NKHF LRNQ PLTF ALQL HDPS GYLA EADL SYTW DFGD SSGT LISR ALVV THTY LEPG PVTA QVVL QAAI PLTS |
| Gene ID: | 6490 |
| Uniprot: | P40967 |
| Cellular Location: | Endoplasmic reticulum membrane, Endosome, Golgi apparatus, Melanosome, Secreted, Single-pass type I membrane protein, multivesicular body |
| Calculated MW: | 60kDa/66kDa/70kDa |
| Observed MW: | 80KDa/105KDa |
| UniProt Protein Function: | SILV: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 12q13-q14 Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; melanosome; plasma membrane; extracellular region; integral to membrane Molecular Function:protein binding Biological Process: melanin biosynthetic process; melanosome organization and biogenesis |
| NCBI Summary: | This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P40967 |
| NCBI GenInfo Identifier: | 2507099 |
| NCBI Gene ID: | 6490 |
| NCBI Accession: | P40967.2 |
| UniProt Secondary Accession: | P40967,Q12763, Q14448, Q14817, Q16565, B3KS57, B7Z6D7 |
| UniProt Related Accession: | P40967 |
| Molecular Weight: | 70,255 Da |
| NCBI Full Name: | Melanocyte protein PMEL |
| NCBI Synonym Full Names: | premelanosome protein |
| NCBI Official Symbol: | PMEL |
| NCBI Official Synonym Symbols: | P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E |
| NCBI Protein Information: | melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100 |
| UniProt Protein Name: | Melanocyte protein PMEL |
| UniProt Synonym Protein Names: | ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homologCleaved into the following 2 chains:M-alpha; Alternative name(s):; 95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen |
| UniProt Gene Name: | PMEL |
| UniProt Entry Name: | PMEL_HUMAN |
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