Neuroscience
Anti-PLXNB3 Antibody (CAB14767)
- SKU:
- CAB14767
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-PLXNB3 Antibody |
| Antibody SKU: | CAB14767 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human PLXNB3 (NP_001156729.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human PLXNB3 (NP_001156729.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RGGG RLIR VRGT GLDV VQRP LLSV WLEA DAEV QASR AQPQ DPQP RRSC GAPA ADPQ ACIQ LGGG LLQC STVC SVNS SSLL LCRS PAVP DRAH PQRV FFTL DNVQ VDFA SASG GQGF LYQP NPRL APLS REGP ARPY RLKP GHVL DVEG EGLN LGIS KEEV RVHI GRGE CLVK TLTR THLY CEPP AHAP QPAN GSGL PQFV V |
| Gene ID: | 5365 |
| Uniprot: | Q9ULL4 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 206kDa/209kDa |
| Observed MW: | 172kDa |
| Synonyms: | PLXNB3, PLEXB3, PLEXR, PLXN6, plexin-B3 |
| Background: | The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. |
| NCBI Summary: | The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9ULL4 |
| NCBI GenInfo Identifier: | 253795481 |
| NCBI Gene ID: | 5365 |
| NCBI Accession: | NP_001156729.1 |
| UniProt Secondary Accession: | Q9ULL4,Q9HDA4, B7Z3E6, F5H773, |
| UniProt Related Accession: | Q9ULL4 |
| Molecular Weight: | 209,301 Da |
| NCBI Full Name: | plexin-B3 isoform 2 |
| NCBI Synonym Full Names: | plexin B3 |
| NCBI Official Symbol: | PLXNB3 |
| NCBI Official Synonym Symbols: | PLEXR; PLXN6; PLEXB3 |
| NCBI Protein Information: | plexin-B3 |
| UniProt Protein Name: | Plexin-B3 |
| Protein Family: | Plexin |
| UniProt Gene Name: | PLXNB3 |
 | Western blot analysis of extracts of rat liver, using PLXNB3 antibody (CAB14767) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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