Cell Biology Antibodies 1

Anti-PLXNB2 Antibody (CAB10069)

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SKU:
CAB10069
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PLXNB2 Antibody
Antibody SKU:CAB10069
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, SH-SY5Y, SKOV3, HepG2, 22Rv1, Mouse brain, Mouse liver, Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALLR TEAG AFEY VPDP TFEN FTGG VKKQ VNKL IHAR GTNL NKAM TLQE AEAF VGAE RCTM KTLT ETDL YCEP PEVQ PPPK RRQK RDTT HNLP EFIV KFGS REWV LGRV EYDT RVSD VPLS L
Gene ID:23654
Uniprot:O15031
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:205kDa
Observed MW:80kDa
Synonyms:PLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin-B2
Background:
UniProt Protein Function:PLXNB2: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: cell surface; integral to plasma membrane; intracellular

Molecular Function:protein binding; semaphorin receptor activity

Biological Process: regulation of cell shape; regulation of protein amino acid phosphorylation; neuroblast proliferation; neural tube closure; positive regulation of axonogenesis; brain development

NCBI Summary:Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
UniProt Code:O15031
NCBI GenInfo Identifier:118341393
NCBI Gene ID:23654
NCBI Accession:AAI27771.1
UniProt Secondary Accession:O15031,Q7KZU3, Q9BSU7, A6QRH0,
UniProt Related Accession:O15031
Molecular Weight:205,127 Da
NCBI Full Name:PLXNB2 protein
NCBI Synonym Full Names:plexin B2
NCBI Official Symbol:PLXNB2  
NCBI Official Synonym Symbols:MM1; PLEXB2; Nbla00445; dJ402G11.3  
NCBI Protein Information:plexin-B2
UniProt Protein Name:Plexin-B2
UniProt Synonym Protein Names:MM1
Protein Family:Plexin
UniProt Gene Name:PLXNB2  
UniProt Entry Name:PLXB2_HUMAN
Anti-PLXNB2 Antibody (CAB10069)Western blot analysis of extracts of various cell lines, using PLXNB2 antibody (CAB10069) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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