Cell Biology Antibodies 5
Anti-PLXNA3 Antibody (CAB14907)
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- SKU:
- CAB14907
Description
| Antibody Name: | Anti-PLXNA3 Antibody |
| Antibody SKU: | CAB14907 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human PLXNA3 (NP_059984.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human PLXNA3 (NP_059984.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GTRL TISG SSLD AGSR VTVT VRDS ECQF VRRD AKAI VCIS PLST LGPS QAPI TLAI DRAN ISSP GLIY TYTQ DPTV TRLE PTWS IING STAI TVSG THLL TVQE PRVR AKYR GIET TNTC QVIN DTAM LCKA PGIF LGRP QPRA QGEH PDEF GFLL DHVQ TARS LNRS SFTY YPDP SFEP LGPS GVLD VKPG SHVV LKGK N |
| Gene ID: | 55558 |
| Uniprot: | P51805 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 207kDa |
| Observed MW: | 208kDa |
| Synonyms: | PLXNA3, 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6, plexin-A3 |
| Background: | This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. |
| UniProt Protein Function: | PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cell junction; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane Molecular Function:protein binding; semaphorin receptor activity Biological Process: branchiomotor neuron axon guidance; multicellular organismal development; regulation of axon extension involved in axon guidance; regulation of cell migration |
| NCBI Summary: | This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P51805 |
| NCBI GenInfo Identifier: | 533112479 |
| NCBI Gene ID: | 55558 |
| NCBI Accession: | NP_059984 |
| UniProt Secondary Accession: | P51805,Q5HY36, |
| UniProt Related Accession: | P51805 |
| Molecular Weight: | |
| NCBI Full Name: | plexin-A3 |
| NCBI Synonym Full Names: | plexin A3 |
| NCBI Official Symbol: | PLXNA3 |
| NCBI Official Synonym Symbols: | 6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE |
| NCBI Protein Information: | plexin-A3 |
| UniProt Protein Name: | Plexin-A3 |
| UniProt Synonym Protein Names: | Plexin-4; Semaphorin receptor SEX |
| Protein Family: | Plexin |
| UniProt Gene Name: | PLXNA3 |
| UniProt Entry Name: | PLXA3_HUMAN |
 | Western blot analysis of extracts of U-251MG cells, using PLXNA3 antibody (CAB14907) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Cell Biology |
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