Cell Biology Antibodies 5

Anti-PLXNA3 Antibody (CAB14907)

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SKU:
CAB14907
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PLXNA3 Antibody
Antibody SKU:CAB14907
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human PLXNA3 (NP_059984.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-251MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human PLXNA3 (NP_059984.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GTRL TISG SSLD AGSR VTVT VRDS ECQF VRRD AKAI VCIS PLST LGPS QAPI TLAI DRAN ISSP GLIY TYTQ DPTV TRLE PTWS IING STAI TVSG THLL TVQE PRVR AKYR GIET TNTC QVIN DTAM LCKA PGIF LGRP QPRA QGEH PDEF GFLL DHVQ TARS LNRS SFTY YPDP SFEP LGPS GVLD VKPG SHVV LKGK N
Gene ID:55558
Uniprot:P51805
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:207kDa
Observed MW:208kDa
Synonyms:PLXNA3, 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6, plexin-A3
Background:This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression.
UniProt Protein Function:PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cell junction; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane

Molecular Function:protein binding; semaphorin receptor activity

Biological Process: branchiomotor neuron axon guidance; multicellular organismal development; regulation of axon extension involved in axon guidance; regulation of cell migration

NCBI Summary:This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]
UniProt Code:P51805
NCBI GenInfo Identifier:533112479
NCBI Gene ID:55558
NCBI Accession:NP_059984
UniProt Secondary Accession:P51805,Q5HY36,
UniProt Related Accession:P51805
Molecular Weight:
NCBI Full Name:plexin-A3
NCBI Synonym Full Names:plexin A3
NCBI Official Symbol:PLXNA3  
NCBI Official Synonym Symbols:6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE  
NCBI Protein Information:plexin-A3
UniProt Protein Name:Plexin-A3
UniProt Synonym Protein Names:Plexin-4; Semaphorin receptor SEX
Protein Family:Plexin
UniProt Gene Name:PLXNA3  
UniProt Entry Name:PLXA3_HUMAN
Anti-PLXNA3 Antibody (CAB14907)Western blot analysis of extracts of U-251MG cells, using PLXNA3 antibody (CAB14907) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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