ChIP Antibodies

Anti-PLRG1 Antibody (CAB9946)

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SKU:
CAB9946

Description

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Antibody Name:Anti-PLRG1 Antibody
Antibody SKU:CAB9946
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PLRG1 (NP_001188493.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PLRG1 (NP_001188493.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVEE VQKH SVHT LVFR SLKR THDM FVAD NGKP VPLD EESH KRKM AIKL RNEY GPVL HMPT SKEN LKEK GPQN ATDS YVHK QYPA NQGQ EVEY FVAG VALT ADTK IQRM PSES AAQS LAVA LPLQ TKAD ANRT APSG SEYR HPGA SDRP QPTA MNSI VMET GNTK NSAL MAKK APTM PKPQ WHPP WKLY RV
Gene ID:5356
Uniprot:O43660
Cellular Location:Nucleus, Nucleus speckle
Calculated MW:56kDa/57kDa
Observed MW:57kDa
Synonyms:PLRG1, Cwc1, PRL1, PRP46, PRPF46, TANGO4
Background:This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:PLRG1: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRL1/PRL2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Spliceosome; RNA splicing; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 4q31.2-q32.1

Cellular Component: DNA replication factor A complex; nuclear membrane; nucleolus; nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: nuclear mRNA splicing, via spliceosome

NCBI Summary:This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Code:O43660
NCBI GenInfo Identifier:38257903
NCBI Gene ID:5356
NCBI Accession:O43660.1
UniProt Secondary Accession:O43660,Q3KQY5, Q8WUD8, B3KMK4,
UniProt Related Accession:O43660
Molecular Weight:56,290 Da
NCBI Full Name:Pleiotropic regulator 1
NCBI Synonym Full Names:pleiotropic regulator 1
NCBI Official Symbol:PLRG1  
NCBI Official Synonym Symbols:Cwc1; PRL1; PRP46; PRPF46; TANGO4  
NCBI Protein Information:pleiotropic regulator 1
UniProt Protein Name:Pleiotropic regulator 1
Protein Family:Pleiotropic regulator
UniProt Gene Name:PLRG1  
UniProt Entry Name:PLRG1_HUMAN
Anti-PLRG1 Polyclonal Antibody (CAB9946)Western blot analysis of extracts of mouse thymus, using PLRG1 antibody (CAB9946) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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Additional Information

Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
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