Cell Biology Antibodies 14
Anti-PLN Antibody (CAB17964)
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- SKU:
- CAB17964
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PLN Antibody |
| Antibody SKU: | CAB17964 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PLN. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse heart, Rat heart |
| Immunogen: | Recombinant protein of human PLN. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5350 |
| Uniprot: | P26678 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 6kDa |
 | Western blot - PLN Polyclonal Antibody (CAB17964) |
| Synonyms: | CMD1P, CMH18, PLB, PLN |
| Background: |
| UniProt Protein Function: | PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Inhibitor Chromosomal Location of Human Ortholog: 6q22.1 Cellular Component: endoplasmic reticulum; membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum membrane Molecular Function:ATPase binding; ATPase inhibitor activity; enzyme inhibitor activity; identical protein binding; protein binding Biological Process: cytosolic calcium ion homeostasis; negative regulation of ATPase activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart rate; regulation of calcium ion transport; regulation of heart contraction; regulation of the force of heart contraction Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18 |
| NCBI Summary: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] |
| UniProt Code: | P26678 |
| NCBI GenInfo Identifier: | 130774 |
| NCBI Gene ID: | 5350 |
| NCBI Accession: | P26678.1 |
| UniProt Secondary Accession: | P26678,P61016, P61015, P61013, P61014, A4IFH6, |
| UniProt Related Accession: | P26678 |
| Molecular Weight: | 6,109 Da |
| NCBI Full Name: | Cardiac phospholamban |
| NCBI Synonym Full Names: | phospholamban |
| NCBI Official Symbol: | PLN |
| NCBI Official Synonym Symbols: | PLB; CMD1P; CMH18 |
| NCBI Protein Information: | cardiac phospholamban |
| UniProt Protein Name: | Cardiac phospholamban |
| Protein Family: | Cardiac phospholamban |
| UniProt Gene Name: | PLN |
| UniProt Entry Name: | PPLA_HUMAN |
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