Cell Cycle Antibodies 1

Anti-PLK5 Antibody (CAB14442)

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SKU:
CAB14442
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-PLK5 Antibody
Antibody SKU:CAB14442
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human PLK5 (NP_001230008.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:U-251MG, 293T, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human PLK5 (NP_001230008.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYTV LTGT PPFM ASPL SEMY QNIR EGHY PEPA HLSA NARR LIVH LLAP NPAE RPSL DHLL QDDF FTQG FTPD RLPA HSCH SPPI FAIP PPLG RIFR KVGQ RLLT QCRP PCPF TPKE ASGP GEGG PDPD SMEW DGES SLSA KEVP CLEG PIHL VAQG TLQS DLAG PEGS RRPE VEAA LRHL QLCL DVGP PATQ DPLG EQQP ILWA PKWV DYSS KYGF GYQL LDGG RTGR HPHG PATP RREG TLPT PVPP AGPG LCLL RFLA SEHA LLLL FSNG MVQV SFSG VPAQ LVLS GEGE GLQL TLWE QGSP GTSY SLDV PRSH GCAP TTGQ HLHH ALRM LQSI
Gene ID:126520
Uniprot:Q496M5
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:32kDa/36kDa
Observed MW:36kDa, 66kDa
Synonyms:PLK5, PLK-5, PLK5P, SgK384ps
Background:
UniProt Protein Function:PLK5: Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell cycle regulation; Nucleolus; Kinase, protein; Protein kinase, Other; EC 2.7.11.21; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family; PLK2 subfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm

Biological Process: defense response to tumor cell; G2/M transition DNA damage checkpoint

UniProt Code:Q496M5
NCBI GenInfo Identifier:308153664
NCBI Gene ID:126520
NCBI Accession:Q496M5.4
UniProt Secondary Accession:Q496M5,Q1ZYM0, B3KNR4,
UniProt Related Accession:Q496M5
Molecular Weight:32,487 Da
NCBI Full Name:Inactive serine/threonine-protein kinase PLK5
NCBI Synonym Full Names:polo like kinase 5
NCBI Official Symbol:PLK5  
NCBI Official Synonym Symbols:PLK-5; PLK5P; SgK384ps  
NCBI Protein Information:inactive serine/threonine-protein kinase PLK5
UniProt Protein Name:Inactive serine/threonine-protein kinase PLK5
UniProt Synonym Protein Names:Polo-like kinase 5; PLK-5
Protein Family:Inactive serine/threonine-protein kinase
UniProt Gene Name:PLK5  
UniProt Entry Name:PLK5_HUMAN
Anti-PLK5 Antibody (CAB14442)Western blot analysis of extracts of various cell lines, using PLK5 antibody (CAB14442) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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