Cell Biology Antibodies 12
Anti-PLK4 Antibody (CAB9863)
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- SKU:
- CAB9863
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PLK4 Antibody |
| Antibody SKU: | CAB9863 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 641-970 of human PLK4 (NP_055079.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, MCF7, HeLa, DU145, Mouse spleen, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 641-970 of human PLK4 (NP_055079.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDGN TITI YYPN GGRG FPLA DRPP SPTD NISR YSFD NLPE KYWR KYQY ASRF VQLV RSKS PKIT YFTR YAKC ILME NSPG ADFE VWFY DGVK IHKT EDFI QVIE KTGK SYTL KSES EVNS LKEE IKMY MDHA NEGH RICL ALES IISE EERK TRSA PFFP IIIG RKPG STSS PKAL SPPP SVDS NYPT RERA SFNR MVMH SAAS PTQA PILN PSMV TNEG LGLT TTAS GTDI SSNS LKDC LPKS AQLL KSVF VKNV GWAT QLTS GAVW VQFN DGSQ LVVQ AGVS SISY TSPN GQTT RYGE NEKL PDYI KQKL QCLS SILL MFSN PTPN FH |
| Gene ID: | 10733 |
| Uniprot: | O00444 |
| Cellular Location: | Cleavage furrow, Cytoplasm, Nucleus, centriole, centrosome, cytoskeleton, microtubule organizing center, nucleolus |
| Calculated MW: | 104kDa/105kDa/108kDa |
| Observed MW: | 115kDa |
| Synonyms: | PLK4, MCCRP2, SAK, STK18 |
| Background: | This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. |
| UniProt Protein Function: | PLK4: a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec. |
| UniProt Protein Details: | Protein type:EC 2.7.11.21; Kinase, protein; Nucleolus; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 4q28.1 Cellular Component: centriole; centrosome; cytosol; nucleolus Molecular Function:identical protein binding; protein binding; protein serine/threonine kinase activity Biological Process: centriole replication; G2/M transition of mitotic cell cycle; positive regulation of centriole replication Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2 |
| NCBI Summary: | This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | O00444 |
| NCBI GenInfo Identifier: | 160113150 |
| NCBI Gene ID: | 10733 |
| NCBI Accession: | O00444.3 |
| UniProt Secondary Accession: | O00444,Q8IYF0, Q96Q95, Q9UD84, Q9UDE2, B2RAL0, B7Z837 B7Z8G7, |
| UniProt Related Accession: | O00444 |
| Molecular Weight: | 109kDa |
| NCBI Full Name: | Serine/threonine-protein kinase PLK4 |
| NCBI Synonym Full Names: | polo like kinase 4 |
| NCBI Official Symbol: | PLK4 |
| NCBI Official Synonym Symbols: | SAK; STK18; MCCRP2 |
| NCBI Protein Information: | serine/threonine-protein kinase PLK4 |
| UniProt Protein Name: | Serine/threonine-protein kinase PLK4 |
| UniProt Synonym Protein Names: | Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase Sak |
| UniProt Gene Name: | PLK4 |
 | Western blot analysis of extracts of various cell lines, using PLK4 antibody (CAB9863) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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