Metabolism Antibodies 2
Anti-PLIN1 Antibody (CAB16295)
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- SKU:
- CAB16295
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PLIN1 Antibody |
| Antibody SKU: | CAB16295 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human PLIN1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2 |
| Immunogen: | A synthetic peptide of human PLIN1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5346 |
| Uniprot: | O60240 |
| Cellular Location: | |
| Calculated MW: | 55kDa |
| Observed MW: | 55kDa |
| Synonyms: | PLIN1, FPLD4, PERI, PLIN |
| Background: | The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. |
| UniProt Protein Function: | perilipin 1: an adipocyte protein of the peripilin family. A modulator of adipocyte lipid metabolism, coating lipid storage droplets to protect them from being broken down by hormone-sensitive lipase. A major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 15q26 Cellular Component: endoplasmic reticulum; lipid particle; cytosol Molecular Function:lipid binding Biological Process: triacylglycerol catabolic process; lipid metabolic process Disease: Lipodystrophy, Familial Partial, Type 4 |
| NCBI Summary: | The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | O60240 |
| NCBI GenInfo Identifier: | 229462739 |
| NCBI Gene ID: | 5346 |
| NCBI Accession: | O60240.2 |
| UniProt Secondary Accession: | O60240,Q8N5Y6, |
| UniProt Related Accession: | O60240 |
| Molecular Weight: | 55,990 Da |
| NCBI Full Name: | Perilipin-1 |
| NCBI Synonym Full Names: | perilipin 1 |
| NCBI Official Symbol: | PLIN1 |
| NCBI Official Synonym Symbols: | PERI; PLIN; FPLD4 |
| NCBI Protein Information: | perilipin-1; lipid droplet-associated protein |
| UniProt Protein Name: | Perilipin-1 |
| UniProt Synonym Protein Names: | Lipid droplet-associated protein |
| Protein Family: | Perilipin |
| UniProt Gene Name: | PLIN1 |
| UniProt Entry Name: | PLIN1_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using PLIN1 antibody (CAB16295) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
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