Cell Biology Antibodies 16
Anti-Plexin-A4 Antibody (CAB9990)
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- SKU:
- CAB9990
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Plexin-A4 Antibody |
| Antibody SKU: | CAB9990 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human PLXNA4 (NP_861440.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human PLXNA4 (NP_861440.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TLLT RQPA PLSQ KQRS FVTF RGEP AEGF NHLV VDER TGHI YLGA VNRI YKLS SDLK VLVT HETG PDED NPKC YPPR IVQT CNEP LTTT NNVN KMLL IDYK ENRL IACG SLYQ GICK LLRL EDLF KLGE PYHK KEHY LSGV NESG SVFG VIVS YSNL DDKL FIAT AVDG KPEY FPTI SSRK LTKN SEAD GMFA YVFH D |
| Gene ID: | 91584 |
| Uniprot: | Q9HCM2 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 39kDa/55kDa/58kDa/212kDa |
| Observed MW: | 212kDa |
| Synonyms: | PLXNA4, FAYV2820, PLEXA4, PLXNA4A, PLXNA4B, PRO34003, plexin-A4 |
| Background: |
| UniProt Protein Function: | PLXNA4: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with NRP1 and NRP2. Belongs to the plexin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 7q32.3 Cellular Component: integral to membrane; plasma membrane; intracellular Molecular Function:semaphorin receptor activity Biological Process: facial nerve structural organization; trigeminal nerve structural organization; axon guidance; sympathetic nervous system development; anterior commissure morphogenesis; glossopharyngeal nerve morphogenesis; regulation of axon extension involved in axon guidance; postganglionic parasympathetic nervous system development; regulation of negative chemotaxis; vagus nerve morphogenesis; chemorepulsion of branchiomotor axon |
| UniProt Code: | Q9HCM2 |
| NCBI GenInfo Identifier: | 108860890 |
| NCBI Gene ID: | 91584 |
| NCBI Accession: | Q9HCM2.4 |
| UniProt Secondary Accession: | Q9HCM2,Q6UWC6, Q6ZW89, Q8N969, Q8ND00, Q8NEN3, Q9NTD4 A4D1N6, E9PAM2, |
| UniProt Related Accession: | Q9HCM2 |
| Molecular Weight: | 39,312 Da |
| NCBI Full Name: | Plexin-A4 |
| NCBI Synonym Full Names: | plexin A4 |
| NCBI Official Symbol: | PLXNA4 |
| NCBI Official Synonym Symbols: | PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003 |
| NCBI Protein Information: | plexin-A4 |
| UniProt Protein Name: | Plexin-A4 |
| Protein Family: | Plexin |
| UniProt Gene Name: | PLXNA4 |
| UniProt Entry Name: | PLXA4_HUMAN |
 | Western blot analysis of extracts of rat lung, using PLXNA4 antibody (CAB9990) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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