Epigenetics & Nuclear Signaling Antibodies 2
Anti-PLEKHA1 Antibody (CAB16009)
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- SKU:
- CAB16009
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PLEKHA1 Antibody |
| Antibody SKU: | CAB16009 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 285-404 of human PLEKHA1 (NP_067635.2). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 285-404 of human PLEKHA1 (NP_067635.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGAI VAQR GPGR SASS EHPP GPSE SKHA FRPT NAAT ATSH STAS RSNS LVST FTME KRGF YESL AKVK PGNF KVQT VSPR EPAS KVTE QALL RPQS KNGP QEKD CDLV DLDD ASLP VSDV |
| Gene ID: | 59338 |
| Uniprot: | Q9HB21 |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
| Calculated MW: | 38kDa/45kDa |
| Observed MW: |
| Synonyms: | PLEKHA1, TAPP1 |
| Background: | This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3, 4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. |
| UniProt Protein Function: | PLEKHA1: Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 10q26.13 Cellular Component: cytoplasm; nucleoplasm; plasma membrane Molecular Function:PDZ domain binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding Biological Process: B cell receptor signaling pathway; establishment of protein localization; negative regulation of protein kinase B signaling cascade; phosphoinositide 3-kinase cascade; ruffle organization and biogenesis Disease: Macular Degeneration, Age-related, 1 |
| NCBI Summary: | This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9HB21 |
| NCBI GenInfo Identifier: | 48474647 |
| NCBI Gene ID: | 59338 |
| NCBI Accession: | Q9HB21.2 |
| UniProt Secondary Accession: | Q9HB21,Q9BVK0, B3KQ55, D3DRE2, |
| UniProt Related Accession: | Q9HB21 |
| Molecular Weight: | 38,113 Da |
| NCBI Full Name: | Pleckstrin homology domain-containing family A member 1 |
| NCBI Synonym Full Names: | pleckstrin homology domain containing A1 |
| NCBI Official Symbol: | PLEKHA1 |
| NCBI Official Synonym Symbols: | TAPP1 |
| NCBI Protein Information: | pleckstrin homology domain-containing family A member 1 |
| UniProt Protein Name: | Pleckstrin homology domain-containing family A member 1 |
| UniProt Synonym Protein Names: | Tandem PH domain-containing protein 1; TAPP-1 |
| Protein Family: | Pleckstrin homology domain-containing family |
| UniProt Gene Name: | PLEKHA1 |
| UniProt Entry Name: | PKHA1_HUMAN |
 | Immunofluorescence analysis of U2OS cells using PLEKHA1 antibody (CAB16009) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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