Cell Biology Antibodies 5

Anti-PLCL1 Antibody (CAB15302)

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SKU:
CAB15302
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PLCL1 Antibody
Antibody SKU:CAB15302
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-350 of human PLCL1 (NP_006217.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse heart, Mouse kidney, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-350 of human PLCL1 (NP_006217.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DCIS FMQA GCEL KKVR PNSR IYNR FFTL DTDL QALR WEPS KKDL EKAK LDIS AIKE IRLG KNTE TFRN NGLA DQIC EDCA FSIL HGEN YESL DLVA NSAD VANI WVSG LRYL VSRS KQPL DFME GNQN TPRF MWLK TVFE AADV DGNG IMLE DTSV ELIK QLNP TLKE AKIR LKFK EIQK SKEK LTTR VTEE EFCE AFCE LCTR PEVY FLLV QISK NKEY LDAN DLML FLEA EQGV THIT E
Gene ID:5334
Uniprot:Q15111
Cellular Location:Cytoplasm
Calculated MW:113kDa/122kDa
Observed MW:140kDa
Synonyms:PLCL1, PLCE, PLCL, PLDL1, PPP1R127, PRIP
Background:
UniProt Protein Function:PLCL1: a protein closely related to phospholipase C-d1 (PLC-d1) but catalytically inactive. First identified as a novel inositol 1,4,5-trisphosphate binding protein. Has a number of binding partners including protein phosphatase (PP1 and 2A), GABA(A) receptor associated protein, and the beta subunits of GABA(A) receptors, in addition to inositol 1,4,5-trisphosphate. Plays an important role in controlling the dynamics of GABA(A) receptor phosphorylation through PP1 binding and, therefore, the efficacy of synaptic inhibition mediated by these receptors.
UniProt Protein Details:

Protein type:Phospholipase

Chromosomal Location of Human Ortholog: 2q33

Molecular Function:phospholipase C activity

UniProt Code:Q15111
NCBI GenInfo Identifier:226694170
NCBI Gene ID:5334
NCBI Accession:Q15111.3
UniProt Secondary Accession:Q15111,Q3MJ90, Q53SD3, Q7Z3S3,
UniProt Related Accession:Q15111
Molecular Weight:113,012 Da
NCBI Full Name:Inactive phospholipase C-like protein 1
NCBI Synonym Full Names:phospholipase C like 1
NCBI Official Symbol:PLCL1  
NCBI Official Synonym Symbols:PLCE; PLCL; PRIP; PLDL1; PPP1R127  
NCBI Protein Information:inactive phospholipase C-like protein 1
UniProt Protein Name:Inactive phospholipase C-like protein 1
UniProt Synonym Protein Names:Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; PRIP
Protein Family:Inactive phospholipase C-like protein
UniProt Gene Name:PLCL1  
UniProt Entry Name:PLCL1_HUMAN
Anti-PLCL1 Antibody (CAB15302)Western blot analysis of extracts of various cell lines, using PLCL1 antibody (CAB15302) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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