Metabolism Antibodies 1
Anti-PLCB3 Antibody (CAB10236)
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- SKU:
- CAB10236
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PLCB3 Antibody |
| Antibody SKU: | CAB10236 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human PLCB3 (NP_000923.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | OVCAR8, Mouse lung, Rat lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human PLCB3 (NP_000923.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VDAE AQRR LEHL RQAL QRLR EVVL DANT TQFK RLKE MNER EKKE LQKI LDRK RHNS ISEA KMRD KHKK EAEL TEIN RRHI TESV NSIR RLEE AQKQ RHDR L |
| Gene ID: | 5331 |
| Uniprot: | Q01970 |
| Cellular Location: | Membrane, Peripheral membrane protein |
| Calculated MW: | 131kDa/138kDa |
| Observed MW: | 160kDa |
| Synonyms: | PLCB3 |
| Background: | This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1, 4, 5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PLCB3: a phosphatidylinositol-specific phospholipase C. Binds to calmodulin. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. |
| UniProt Protein Details: | Protein type:Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytosol; nucleoplasm; protein complex; sarcolemma Molecular Function:calcium ion binding; calmodulin binding; phosphoinositide phospholipase C activity; phospholipase C activity; signal transducer activity Biological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate metabolic process; lipid catabolic process; post-Golgi vesicle-mediated transport; regulation of systemic arterial blood pressure; synaptic transmission |
| NCBI Summary: | This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| UniProt Code: | Q01970 |
| NCBI GenInfo Identifier: | 1730573 |
| NCBI Gene ID: | 5331 |
| NCBI Accession: | Q01970.2 |
| UniProt Secondary Accession: | Q01970,Q8N1A4, A5PKZ6, G5E960, |
| UniProt Related Accession: | Q01970 |
| Molecular Weight: | 131,205 Da |
| NCBI Full Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
| NCBI Synonym Full Names: | phospholipase C beta 3 |
| NCBI Official Symbol: | PLCB3 |
| NCBI Protein Information: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
| UniProt Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
| UniProt Synonym Protein Names: | Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3 |
| Protein Family: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
| UniProt Gene Name: | PLCB3 |
| UniProt Entry Name: | PLCB3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLCB3 antibody (CAB10236) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using PLCB3 Rabbit pAb (CAB10236) at dilution of 1:100 (40x lens). |
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