Metabolism Antibodies 3
Anti-PLCB2 Antibody (CAB8141)
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- SKU:
- CAB8141
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | PLCB2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8141 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human PLCB2 (NP_001271228.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, U-937, Mouse thymus, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human PLCB2 (NP_001271228.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSLL NPVL LPPK VKAY LSQG ERFI KWDD ETTV ASPV ILRV DPKG YYLY WTYQ SKEM EFLD ITSI RDTR FGKF AKMP KSQK LRDV FNMD FPDN SFLL KTLT VVSG PDMV DLTF HNFV SYKE NVGK AWAE DVLA LVKH PLTA NASR STFL DKIL VKLK MQLN SEGK IPVK NFFQ MFPA DRKR VEAA LSAC HLPK GKPG GAR |
| Gene ID: | 5330 |
| Uniprot: | Q00722 |
| Cellular Location: | |
| Calculated MW: | 132kDa/133kDa/134kDa |
| Observed MW: | 150kDa |
| Synonyms: | PLCB2, PLC-beta-2 |
| Background: | The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4, 5-bisphosphate to the second messengers inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. |
| UniProt Protein Function: | PLCB2: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11 Chromosomal Location of Human Ortholog: 15q15 Cellular Component: cytosol Molecular Function:phosphoinositide phospholipase C activity; phospholipase C activity Biological Process: inositol phosphate metabolic process; phospholipase C activation; phospholipid metabolic process; Wnt receptor signaling pathway, calcium modulating pathway |
| UniProt Code: | Q00722 |
| NCBI GenInfo Identifier: | 215273902 |
| NCBI Gene ID: | 5330 |
| NCBI Accession: | Q00722.2 |
| UniProt Secondary Accession: | Q00722,A8K6J2, B9EGH5, |
| UniProt Related Accession: | Q00722 |
| Molecular Weight: | 132,511 Da |
| NCBI Full Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
| NCBI Synonym Full Names: | phospholipase C beta 2 |
| NCBI Official Symbol: | PLCB2 |
| NCBI Official Synonym Symbols: | PLC-beta-2 |
| NCBI Protein Information: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
| UniProt Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
| UniProt Synonym Protein Names: | Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2 |
| Protein Family: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
| UniProt Gene Name: | PLCB2 |
| UniProt Entry Name: | PLCB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLCB2 antibody (CAB8141) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human stomach using PLCB2 antibody (CAB8141) at dilution of 1:100 (40x lens). |
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