Cell Biology Antibodies 4
Anti-PLAUR Antibody (CAB1397)
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- SKU:
- CAB1397
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PLAUR Antibody |
| Antibody SKU: | CAB1397 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR (NP_002650.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | DU145, HT-1080, A-549, HeLa, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR (NP_002650.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LRCM QCKT NGDC RVEE CALG QDLC RTTI VRLW EEGE ELEL VEKS CTHS EKTN RTLS YRTG LKIT SLTE VVCG LDLC NQGN SGRA VTYS RSRY LECI SCGS SDMS CERG RHQS LQCR SPEE QCLD VVTH WIQE GEEG RPKD DRHL RGCG YLPG CPGS NGFH NNDT FHFL KCCN TTKC NEGP ILEL ENLP QNGR QCYS CKGN STHG CSSE ETFL IDCR GPMN QCLV ATGT HEPK NQSY MVRG CATA SMCQ HAHL GDAF SMNH IDVS CCTK SGCN HPDL DVQY RSG |
| Gene ID: | 5329 |
| Uniprot: | Q03405 |
| Cellular Location: | Cell membrane, Cell projection, GPI-anchor, Lipid-anchor, Secreted, invadopodium membrane |
| Calculated MW: | 31kDa/32kDa/36kDa |
| Observed MW: | 36-72kDa |
| Synonyms: | PLAUR, CD87, U-PAR, UPAR, URKR |
| Background: | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. |
| UniProt Protein Function: | uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13 Cellular Component: endoplasmic reticulum membrane; focal adhesion; extrinsic to membrane; integral to plasma membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane Molecular Function:protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor activity; receptor binding Biological Process: fibrinolysis; cellular protein metabolic process; regulation of proteolysis; attachment of GPI anchor to protein; C-terminal protein lipidation; post-translational protein modification; cell motility; chemotaxis; signal transduction; blood coagulation |
| NCBI Summary: | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03405 |
| NCBI GenInfo Identifier: | 465003 |
| NCBI Gene ID: | 5329 |
| NCBI Accession: | Q03405.1 |
| UniProt Secondary Accession: | Q03405,Q12876, Q15845, Q16887, Q6IB52, Q9BWT0, Q9NYC8 Q9UD69, Q9UEA6, Q9UM92, Q9UMV0, A8K409, |
| UniProt Related Accession: | Q03405 |
| Molecular Weight: | 32,016 Da |
| NCBI Full Name: | Urokinase plasminogen activator surface receptor |
| NCBI Synonym Full Names: | plasminogen activator, urokinase receptor |
| NCBI Official Symbol: | PLAUR |
| NCBI Official Synonym Symbols: | CD87; UPAR; URKR; U-PAR |
| NCBI Protein Information: | urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor |
| UniProt Protein Name: | Urokinase plasminogen activator surface receptor |
| UniProt Synonym Protein Names: | Monocyte activation antigen Mo3; CD_antigen: CD87 |
| Protein Family: | Urokinase plasminogen activator surface receptor |
| UniProt Gene Name: | PLAUR |
| UniProt Entry Name: | UPAR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLAUR antibody (CAB1397) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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