Cardiovascular Antibodies
Anti-PLAT Antibody (CAB5655)
- SKU:
- CAB5655
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Antibody Name: | Anti-PLAT Antibody |
Antibody SKU: | CAB5655 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-320 of human PLAT (NP_000921.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | NCI-H460 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-320 of human PLAT (NP_000921.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | SQEI HARF RRGA RSYQ VICR DEKT QMIY QQHQ SWLR PVLR SNRV EYCW CNSG RAQC HSVP VKSC SEPR CFNG GTCQ QALY FSDF VCQC PEGF AGKC CEID TRAT CYED QGIS YRGT WSTA ESGA ECTN WNSS ALAQ KPYS GRRP DAIR LGLG NHNY CRNP DRDS KPWC YVFK AGKY SSEF CSTP ACSE GNSD CYFG NGSA YRGT HSLT ESGA SCLP WNSM ILIG KVYT AQNP SAQA LGLG KHNY CRNP DGDA KPWC HVLK NRRL TWEY CDVP SCST CGLR QYSQ PQFR IKGG LFAD IA |
Gene ID: | 5327 |
Uniprot: | P00750 |
Cellular Location: | Secreted, extracellular space |
Calculated MW: | 32kDa/44kDa/57kDa/62kDa |
Observed MW: | 63kDa |
Synonyms: | PLAT, T-PA, TPA |
Background: | This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
UniProt Protein Function: | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. |
NCBI Summary: | This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | P00750 |
NCBI GenInfo Identifier: | 137119 |
NCBI Gene ID: | 5327 |
NCBI Accession: | P00750.1 |
UniProt Secondary Accession: | P00750,Q15103, Q503B0, Q6PJA5, Q7Z7N2, Q86YK8, Q9BU99 Q9BZW1, A8K022, B2R8E8, |
UniProt Related Accession: | P00750 |
Molecular Weight: | 44,373 Da |
NCBI Full Name: | Tissue-type plasminogen activator |
NCBI Synonym Full Names: | plasminogen activator, tissue type |
NCBI Official Symbol: | PLAT |
NCBI Official Synonym Symbols: | TPA; T-PA |
NCBI Protein Information: | tissue-type plasminogen activator |
UniProt Protein Name: | Tissue-type plasminogen activator |
UniProt Synonym Protein Names: | INN: Alteplase; INN: Reteplase |
Protein Family: | Taurine--pyruvate aminotransferase |
UniProt Gene Name: | PLAT |
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