Name: Anti-PLA2G5 Antibody (CAB16711)
Brand: Metabolism Antibodies 2
SKU: CAB16711
Availability: OutOfStock

Antibody Name:	Anti-PLA2G5 Antibody
Antibody SKU:	CAB16711
Antibody Size:	20uL, 50uL, 100uL
Application:	IF
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human PLA2G5 (NP_000920.1).

Application:	IF
Recommended Dilution:	IF 1:50 - 1:200
Reactivity:	Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human PLA2G5 (NP_000920.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MKGL LPLA WFLA CSVP AVQG GLLD LKSM IEKV TGKN ALTN YGFY GCYC GWGG RGTP KDGT DWCC WAHD HCYG RLEE KGCN IRTQ SYKY RFAW GVVT CEPG PFCH VNLC ACDR KLVY CLKR NLRS YNPQ YQYF PNIL CS
Gene ID:	5322
Uniprot:	P39877
Cellular Location:
Calculated MW:	15kDa
Observed MW:	Refer to figures

Synonyms:

PLA2G5, FRFB, GV-PLA2, PLA2-10, hVPLA(2)

Background:

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

UniProt Protein Function:	PLA2G5: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. Defects in PLA2G5 are the cause of fleck retina, familial benign (FRFB). An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. Belongs to the phospholipase A2 family.
UniProt Protein Details:	Protein type:Secreted; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - glycerophospholipid; Secreted, signal peptide; Lipid Metabolism - linoleic acid; Cell surface; Phospholipase; Lipid Metabolism - ether lipid; EC 3.1.1.4; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 1p36-p34 Cellular Component: extracellular region Molecular Function:phospholipase A2 activity Biological Process: phosphatidic acid biosynthetic process; phospholipid metabolic process Disease: Fleck Retina, Familial Benign
NCBI Summary:	This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:	P39877
NCBI GenInfo Identifier:	730258
NCBI Gene ID:	5322
NCBI Accession:	P39877.1
UniProt Secondary Accession:	P39877,Q8N435,
UniProt Related Accession:	P39877
Molecular Weight:
NCBI Full Name:	Calcium-dependent phospholipase A2
NCBI Synonym Full Names:	phospholipase A2 group V
NCBI Official Symbol:	PLA2G5
NCBI Official Synonym Symbols:	FRFB; GV-PLA2; PLA2-10; hVPLA(2)
NCBI Protein Information:	calcium-dependent phospholipase A2
UniProt Protein Name:	Calcium-dependent phospholipase A2
UniProt Synonym Protein Names:	Group V phospholipase A2; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5
Protein Family:	Calcium-dependent phospholipase
UniProt Gene Name:	PLA2G5
UniProt Entry Name:	PA2G5_HUMAN